Genetic Testing + Education for Flushing
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to learn whether education plus genetic testing for ALDH2\*2 and ADH1B\*2 is feasible and acceptable and whether it influences modifiable health behaviors in East Asian American adults who experience alcohol flushing when they drink alcohol or have a family history of flushing. The main questions it aims to answer are:
1. Is providing education plus ALDH2\*2/ADH1B\*2 genetic testing feasible and acceptable in a clinical care context?
2. Does receiving genetic testing results plus education lead to changes in modifiable health behaviors compared with education alone? Researchers will compare education plus genetic testing (intervention arm) to education only (control arm) to see if adding genetic testing improves feasibility/acceptability and supports health behavior change.
Participants will:
1. Complete an education module about alcohol flushing and ALDH2/ADH1B
2. Be randomized to either: (A) Receive genetic testing for ALDH2\*2 and ADH1B\*2 with results disclosure, or (B) Receive education only.
3. Complete follow-up measures about feasibility, acceptability, and modifiable health behaviors
Who Is on the Research Team?
Jennifer L Young, PhD
Principal Investigator
Northwestern U
Are You a Good Fit for This Trial?
This trial is for East Asian American adults who experience alcohol flushing or have a family history of it. It's focused on whether adding genetic testing to education about alcohol flushing can change health behaviors.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Education Module
Participants complete an education module about alcohol flushing and ALDH2/ADH1B
Intervention
Participants are randomized to either receive genetic testing with results disclosure or education only
Follow-up
Participants complete follow-up measures about feasibility, acceptability, and modifiable health behaviors
What Are the Treatments Tested in This Trial?
Interventions
- ALDH2 Genetic Testing
Trial Overview
The study tests if providing ALDH2*2/ADH1B*2 genetic testing along with education is more effective than just education in influencing health behavior changes related to rosacea, Alzheimer's, esophageal cancer, and cardiovascular disease.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northwestern University
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Northwestern University Feinberg School of Medicine
Collaborator
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