Tyrosol + Creatine for Endurance and Strength
Trial Summary
What is the purpose of this trial?
The purpose of this clinical trial is to look at tyrosol's effects on endurance, strength, and fatigue resistance in humans. Additionally, the combination of tyrosol and creatine monohydrate will also be looked at to determine if there is a cooperative effect from using both together. It will be conducted over a 4-week period to compare the effects of the following substances: 1) tyrosol, 2) a placebo (a look-alike substance that contains no drug), 3) creatine, and 4) a combination containing both creatine and tyrosol. Endurance, strength, and fatigue resistance will be compared between groups through repeated testing (described below).Participants who pass initial screening will be invited on-site for day one (Visit 1) of testing where they will proceed with a series of tests which will include the following: (1) body composition; (2) cognitive testing; (3) full-body strength testing; (4) grip strength on both hands; (5) muscle power testing; (6 \& 7) Resting blood lactic acid testing followed by 5RM (repetition maximum) bench press, leading to multiple sets of bench press (based on the previous weight) completed to failure, followed by another blood lactic acid reading; (8) a repeat of the muscle power testing; (9) a 1 mile time trial run completed as fast as possible.After the 4-week supplementation period (\~28-34 days), all original measures will be repeated as before in the same order (Visit 2). Approximately 24 hours later (Visit 3) participants will then repeat all physical testing procedures except tests 1, 6, 7, and 8, to determine physical recovery. Additionally, questionnaires for soreness and perceived recovery will also be completed at the beginning of Visit 2 and 3, and again on its own as the only testing event at 48 hours post-Visit 2 (visit 4).
Research Team
Eric Sikorski, PhD
Principal Investigator
Applied Science and Performance Institute
Eligibility Criteria
Healthy adults aged 18-50 who are moderately active at least twice a week, with good cardiovascular fitness (VO2 max in the top 50% for their age). They must not have had recent injuries or surgeries, be non-smokers and light drinkers, and avoid other supplements that affect muscle strength or endurance during the study. Women must share menstrual cycle information.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Testing
Participants undergo a series of baseline tests including body composition, cognitive testing, strength testing, and endurance testing
Treatment
Participants receive daily supplementation of tyrosol, creatine, or placebo for 4 weeks
Post-Treatment Testing
All baseline measures are repeated to assess the effects of the supplementation
Follow-up
Participants are monitored for recovery and any adverse events post-treatment
Treatment Details
Interventions
- Creatine
- Tyrosol
Find a Clinic Near You
Who Is Running the Clinical Trial?
Applied Science & Performance Institute
Lead Sponsor