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Almonds for Wrinkles

N/A

Recruiting

Led By Raja Sivamani, MD MS AP

Research Sponsored by Integrative Skin Science and Research

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 weeks

Awards & highlights

Study Summary

This trial examines how eating almonds affects skin health in women of different ages and skin tones.

Who is the study for?

This trial is for premenopausal and postmenopausal women aged 35-70, with a BMI of 18.5-35 kg/m2, who have maintained their diet and skincare routine for at least 1 month. It's not suitable for those with nut allergies, on oral collagen or vitamin E supplements, pregnant/breastfeeding women, recent facial procedure recipients, tobacco users, or individuals with certain skin diseases.Check my eligibility

What is being tested?

The study examines if eating whole almonds affects the production of collagen in the skin and improves wrinkles and pigmentation among women of all Fitzpatrick skin types. Participants will be compared to those consuming a non-nut snack to see differences in skin health outcomes.See study design

What are the potential side effects?

Since this trial involves food consumption (whole almonds), potential side effects may include digestive discomfort or allergic reactions for those sensitive to nuts. However, individuals with known nut allergies are excluded from participation.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Facial wrinkles

Skin collagen and elastin quantification

Secondary outcome measures

Expression of enzymes that either degrade collagen (MMP1) or inhibit collagen degradation (TIMP1) on skin biopsies

Facial Wrinkles

Pigment intensity score

+1 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: AlmondsExperimental Treatment1 Intervention

Consumption of almonds 5 times per week

Group II: Control SnackPlacebo Group1 Intervention

Consumption of protein and calorie matched non-nut-based food 5 times per week

Do I qualify?Apply below to find out

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Who is running the clinical trial?

Integrative Skin Science and ResearchLead Sponsor

31 Previous Clinical Trials

2,672 Total Patients Enrolled

Raja Sivamani, MD MS APPrincipal InvestigatorIntegrative Skin Science and Research

4 Previous Clinical Trials

136 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the eligibility requirements for involvement in this clinical research?

"The eligibility criteria for inclusion in this trial is having age between 35 and 70 years old, as well as signs of pigmentation. 60 individuals are being accepted into the study."

Answered by AI

Is the age range for this experiment extended to include individuals over 65?

"This medical study is only available for adults between the ages of 35 and 70. There are 3 trials designed specifically for minors, while 31 clinical studies are dedicated to seniors over 65."

Answered by AI

Is enrollment for this research endeavor still open?

"Affirmative. Clinicaltrials.gov reveals that this trial, first published on October 4th 2023, is currently seeking participants. Sixty patients must be recruited from one primary site."

Answered by AI

What is the aggregate of participants in this research project?

"Affirmative. As evidenced on clinicaltrials.gov, this medical research is actively enrolling participants since its original posting date of October 4th 2023 and last update occurring on the 6th of that same month. The trial requires a total of 60 people from 1 site to complete it."

Answered by AI

What aims is this clinical trial hoping to accomplish?

"Over the course of 24 weeks, this clinical trial aims to observe changes in facial wrinkles. Secondary outcomes include histological assessment of MMP1 and TIMP1 enzymes on skin biopsies, evaluation of advanced glycation end products from plasma samples, and a wrinkle severity score taken via 3D imaging analysis."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

The Effects of Almond on Facial Skin Collagen and Wrinkles

2023. "The Effects of Almond on Facial Skin Collagen and Wrinkles". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06074276.