60 Participants Needed

Almonds for Wrinkles

SA
Overseen BySarah Adnan
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: Integrative Skin Science and Research
Approved in 1 JurisdictionThis treatment is already approved in other countries

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether eating almonds can improve skin health by boosting collagen, enhancing elastin, and reducing wrinkles and pigmentation. Participants will consume either almonds or a non-nut snack five times a week. The trial seeks women ages 35 to 70 who maintain their usual diet and skincare routine. It may be suitable for those who have used the same skincare products for at least a month and have not undergone recent cosmetic procedures. As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research on natural methods to enhance skin health.

Do I need to stop taking my current medications for the trial?

The trial does not specify if you need to stop taking your current medications, but you must stop taking oral collagen supplements one month before the study and vitamin E or nut-containing supplements two weeks before and during the study.

Is there any evidence suggesting that almond consumption is likely to be safe?

Studies have shown that almonds are generally safe for consumption. The Expert Panel for Cosmetic Ingredient Safety reviewed sweet almonds (Prunus Amygdalus Dulcis) and found no major safety concerns. Almonds contain antioxidants, which protect cells from damage and may support skin health and other benefits.

While most people can eat almonds without issues, allergies are a concern. Some individuals are allergic to nuts, including almonds, which can cause reactions. For those without allergies, consuming almonds in normal amounts is usually safe.

In summary, research indicates that almonds are safe to consume and may offer health benefits. However, individuals with nut allergies should avoid them.12345

Why are researchers excited about this trial?

Unlike most anti-wrinkle treatments, which often involve topical creams or invasive procedures, almonds offer a natural, dietary approach. This treatment is unique because it leverages the potential skin benefits of almonds, known for their rich vitamin E and antioxidant content, which may help improve skin health from the inside out. Researchers are excited about this treatment because it promises a non-invasive, easily accessible option that could complement or even reduce the need for other more conventional wrinkle treatments.

What evidence suggests that almond consumption might be effective for reducing wrinkles?

Research has shown that eating almonds can help reduce wrinkles. In one study, participants who ate almonds had fewer wrinkles after 16 to 24 weeks. Another study found that postmenopausal women who ate almonds daily had fewer wrinkles and might experience anti-aging benefits. Almonds are rich in nutrients and antioxidants, which help fight aging and maintain healthy skin. In this trial, participants will consume almonds five times per week to evaluate their effect on skin appearance. These findings suggest that almonds might improve skin appearance in women.678910

Who Is on the Research Team?

RS

Raja Sivamani, MD MS AP

Principal Investigator

Integrative Skin Science and Research

Are You a Good Fit for This Trial?

This trial is for premenopausal and postmenopausal women aged 35-70, with a BMI of 18.5-35 kg/m2, who have maintained their diet and skincare routine for at least 1 month. It's not suitable for those with nut allergies, on oral collagen or vitamin E supplements, pregnant/breastfeeding women, recent facial procedure recipients, tobacco users, or individuals with certain skin diseases.

Inclusion Criteria

You have been following the same diet for the past 6 months and will continue to do so during the study.
I am a postmenopausal woman, having not had a period for over a year.
I am between 35 and 70 years old.
See 3 more

Exclusion Criteria

Individuals who are unwilling to discontinue vitamin E or nut containing supplements 2 weeks prior to and during the intervention
I am willing to stop taking oral collagen supplements 1 month before the study starts.
I have a condition that affects my skin's reaction to sunlight or causes weak collagen.
See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants consume almonds or a placebo snack 5 times per week

24 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Almond
Trial Overview The study examines if eating whole almonds affects the production of collagen in the skin and improves wrinkles and pigmentation among women of all Fitzpatrick skin types. Participants will be compared to those consuming a non-nut snack to see differences in skin health outcomes.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Placebo Group
Group I: AlmondsExperimental Treatment1 Intervention
Group II: Control SnackPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Integrative Skin Science and Research

Lead Sponsor

Trials
33
Recruited
2,000+

Citations

1.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/33673587/
Prospective Randomized Controlled Trial on the Effects of ...Results: The average wrinkle severity was significantly decreased in the almond intervention group at week 16 and week 24 compared to baseline ...
Comparative analysis of nutritional value and antioxidant ...Our research revealed that almonds are rich in minerals, and they displayed low levels of primary oxidation by-products and excellent stability.
3.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/31576607/
Prospective randomized controlled pilot study on the ...Our study demonstrates that daily almond consumption may reduce wrinkle severity in postmenopausal females to potentially have natural antiaging benefits.
Prospective Randomized Controlled Trial on the Effects of ...Results: The average wrinkle severity was significantly decreased in the almond intervention group at week 16 and week 24 compared to baseline ...
Antioxidant Activity of a Sicilian Almond Skin Extract Using ...Notably, almond skin extract (ASE) has shown promising effects in preventing cellular aging and enhancing antioxidant activity. These benefits have been ...
Safety Assessment of Prunus Amygdalus Dulcis (Sweet ...The Expert Panel for Cosmetic Ingredient Safety (Panel) first published a review of the safety of Prunus Amygdalus Dulcis. (Sweet Almond) Seed ...
Antioxidant Activity of a Sicilian Almond Skin Extract Using In ...Notably, almond skin extract (ASE) has shown promising effects in preventing cellular aging and enhancing antioxidant activity. These benefits have been ...
Characterization of polyphenols, lipids, fibre from almond skinsWe analyzed both types of almond skin for phenolic compounds (by HPLC), lipids (by solvent extraction), proteins (by micro-Kjeldahl), and fibre content.
The Antimicrobial and Antiviral Activity of Polyphenols from ...Here, we tested the antibacterial and antiviral effect of a mix of polyphenols present in natural almond skin (NS MIX).
Review of the Sensory and Chemical Characteristics....pdfRaw almond kernels contain fewer volatile organic compounds in comparison with dry-roasted kernels, as detected by gas chromatography.23.
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