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Behavioral Intervention

Contingency Management for Stimulant Use Disorder (MIMIC2 Trial)

Waitlist Available
Led By Sara Becker
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up 10 months
Awards & highlights


This trial will evaluate a multi-level implementation strategy to install contingency management for stimulant use in 10 public opioid treatment programs. It will measure outcomes, provide staff feedback & rigorously evaluate its effectiveness.

Who is the study for?
This trial is for adults who are currently receiving medication for opioid use disorders within the last 30 days and also use stimulants, as shown by self-report or positive tests. They must be actively managing patient cases and providing psychosocial support. It's not open to those under 18, unable to consent, or without electronic medical records.Check my eligibility
What is being tested?
The study is testing a strategy called Science of Service Laboratory designed to help opioid treatment programs implement contingency management for patients with stimulant use disorder. The effectiveness of this multi-level approach will be measured in terms of its adoption by staff and impact on patient outcomes.See study design
What are the potential side effects?
Since this trial focuses on implementing a service strategy rather than a drug, it does not have traditional side effects. However, there may be challenges related to adapting new practices that could affect staff performance and patient care.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in percent of counselors delivering contingency management from pre-implementation to post-implementation
Change in percent of patients receiving contingency management from pre-implementation to post-implementation
Secondary outcome measures
Change in number of contingency management sessions
Change in the percent of toxicology screens negative for stimulants

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Science of Service Laboratory implementation strategyExperimental Treatment1 Intervention
The Science of Service Laboratory implementation strategy consists of: didactic training (contingency management workshops; monthly contingency management coaching calls), performance feedback (practice sessions and electronic medical record feedback); and facilitation (monthly facilitation calls).
Group II: Stepped wedge comparatorActive Control1 Intervention
Our hybrid trial uses a unidirectional crossover stepped wedge design. All sites cross over in the same direction from usual care to intervention. All sites therefore act as their own comparison prior to the sequential roll-out of the implementation strategy.

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Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)NIH
2,503 Previous Clinical Trials
2,625,507 Total Patients Enrolled
Stanford UniversityOTHER
2,411 Previous Clinical Trials
17,462,863 Total Patients Enrolled
Northwestern UniversityLead Sponsor
1,608 Previous Clinical Trials
927,241 Total Patients Enrolled

Media Library

Science to Service Laboratory (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05702021 — N/A
Stimulant Use Disorder Research Study Groups: Science of Service Laboratory implementation strategy, Stepped wedge comparator
Stimulant Use Disorder Clinical Trial 2023: Science to Service Laboratory Highlights & Side Effects. Trial Name: NCT05702021 — N/A
Science to Service Laboratory (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05702021 — N/A
~51 spots leftby Apr 2027