Study Summary
This trial is looking for genetic variants associated with the effects of a GLP1R agonist on insulin secretion and glucose metabolism in overweight/obese, otherwise healthy Amish volunteers.
Eligible Conditions
- Diabetes
- Obesity
Treatment Effectiveness
Study Objectives
3 Primary · 1 Secondary · Reporting Duration: Assessed after completing 6 weeks of semaglutide therapy
Week 6
Weight loss
Week 6
Insulin
Glucose effectiveness (Sg)
Insulin sensitivity (Si)
Rate of glucose disappearance
Second phase insulin secretion
Trial Safety
Trial Design
1 Treatment Group
Open label administration of semaglutide
1 of 1
Experimental Treatment
600 Total Participants · 1 Treatment Group
Primary Treatment: Semaglutide Pen Injector [Ozempic] · No Placebo Group · Phase 1
Open label administration of semaglutide
Drug
Experimental Group · 1 Intervention: Semaglutide Pen Injector [Ozempic] · Intervention Types: DrugTrial Logistics
Logistics
Participation is compensated
You will be compensated for participating in this trial.
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: assessed after completing 6 weeks of semaglutide therapy
Who is running the clinical trial?
University of Maryland, BaltimoreLead Sponsor
610 Previous Clinical Trials
333,205 Total Patients Enrolled
3 Trials studying Diabetes
3,990 Patients Enrolled for Diabetes
Amber L Beitelshees, PharmDPrincipal InvestigatorUniversity of Maryland, Baltimore
Eligibility Criteria
Age 18 - 89 · All Participants · 2 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:You have a body mass index (BMI) greater than or equal to 27 kg/m2.
Who else is applying?
What state do they live in?
| Illinois | 50.0% |
| Ohio | 50.0% |
How old are they?
| 18 - 65 | 100.0% |
What site did they apply to?
| Amish Research Clinic | 100.0% |
What portion of applicants met pre-screening criteria?
| Did not meet criteria | 50.0% |
| Met criteria | 50.0% |
Why did patients apply to this trial?
- "I want to lose weight but can't afford medicine"
How many prior treatments have patients received?
| 1 | 100.0% |
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Conditions
Cancer Related
Treatments