Exercise for Type 2 Diabetes
(ADA Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
In this randomized controlled trial, 30 older adults (aged\> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitness and muscle performance testing; dietary protein efficiency assessed using the indicator amino acid oxidation (IAAO) method; and a gut microbiota trial. The dietary protein efficiency trial will include repeated ingestion of crystallized amino acids (drink) containing stable isotopes, urine samples, and breath samples. The gut microbiome trial will consist of a single ingestion of a Mediterranean-based modeled meal enriched with 13C-phenylalanine (in the drink) and repeated blood draws. Participants will also be asked to give a fecal sample after the gut microbiome trial.
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Preliminary Testing
Participants undergo pre-testing including body composition, glucose tolerance, cardiovascular fitness, and muscle performance assessments
Exercise Training
Participants engage in a 12-week progressive exercise training program including strength and endurance training
Post-Testing
Participants undergo post-testing similar to pre-testing to assess changes after the exercise intervention
Follow-up
Participants are monitored for safety and effectiveness after the intervention
What Are the Treatments Tested in This Trial?
Interventions
- Exercise
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Diagnosed diabetic group. Will complete all pre- and post-testing and the 12-week intervention period.
Non-diabetic control group. Will be assigned to all pre-/post-testing and complete the 12-week intervention period.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Illinois at Urbana-Champaign
Lead Sponsor
American Diabetes Association
Collaborator
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