CLINICAL TRIAL

Computer Task Manipulation for Melancholia

Recruiting · < 65 · Female · Belmont, MA

Neural Correlates of Stress and Perceived Control in Adolescent Depression

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About the trial for Melancholia

Eligible Conditions
Depressive Disorder, Major · Depressive Disorder · Depression · Major Depressive Disorder (MDD)

Treatment Groups

This trial involves 2 different treatments. Computer Task Manipulation is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Computer Task Manipulation
BEHAVIORAL
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for female patients aged 65 and younger. There are 10 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
No use of any psychotropic medications for at least 2 weeks (6 weeks for fluoxetine; 6 months for neuroleptics; 2 weeks for benzodiazepines; 2 weeks for any other antidepressants). show original
Adolescents must provide written informed assent if they are older than age 7 and younger than age 18, and a parent or guardian must provide written informed consent if the adolescent is younger than age 7. show original
All participants will have their menstrual cycle monitored to ensure they are in the follicular phase when completing the fMRI study session. show original
Inclusion Criteria: MDD Sample
Inclusion Criteria: All Participants
According to the report, all ethnicities of women should be included in all activities. show original
All children between the ages of 14 and 18 are eligible to enroll in the program. show original
Right handed111;
The following text describes the diagnostic criteria for Major Depressive Disorder as diagnosed with the KSADS. show original
these are the two main goals of our English language program show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Longitudinal, three time points (baseline, 3-month follow-up, 6-month follow-up)
Screening: ~3 weeks
Treatment: Varies
Reporting: Longitudinal, three time points (baseline, 3-month follow-up, 6-month follow-up)
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Longitudinal, three time points (baseline, 3-month follow-up, 6-month follow-up).
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Computer Task Manipulation will improve 1 primary outcome and 5 secondary outcomes in patients with Melancholia. Measurement will happen over the course of collected as part of 1.5 hour long scan during session 2.

Mood Rating
COLLECTED AS PART OF 1.5 HOUR LONG SCAN DURING SESSION 2
Self-reported mood rating to be collected throughout the fMRI brain scan
COLLECTED AS PART OF 1.5 HOUR LONG SCAN DURING SESSION 2
Cortisol Rating
COLLECTED AS PART OF 1.5 HOUR LONG SCAN DURING SESSION 2
Saliva rating to be collected throughout the fMRI brain scan
COLLECTED AS PART OF 1.5 HOUR LONG SCAN DURING SESSION 2
Blood-Oxygen-Level-Dependent Imaging (BOLD) activation of the ventral striatum and ventral medial prefrontal cortex
1.5 HOUR LONG SCAN DURING SESSION 2
BOLD activation of frontostriatal regions in response to computer tasks performed during the fMRI Brian scan
1.5 HOUR LONG SCAN DURING SESSION 2
Stress Reactive Rumination Score
LONGITUDINAL, THREE TIME POINTS (BASELINE, 3-MONTH FOLLOW-UP, 6-MONTH FOLLOW-UP)
Stress Reactive Rumination Scale collected via smart-phone delivered ecological momentary assessment
LONGITUDINAL, THREE TIME POINTS (BASELINE, 3-MONTH FOLLOW-UP, 6-MONTH FOLLOW-UP)
Positive Affect Score
LONGITUDINAL, THREE TIME POINTS (BASELINE, 3-MONTH FOLLOW-UP, 6-MONTH FOLLOW-UP)
Positive Affect Survey Items collected via smart-phone delivered ecological momentary assessment
LONGITUDINAL, THREE TIME POINTS (BASELINE, 3-MONTH FOLLOW-UP, 6-MONTH FOLLOW-UP)
Stress Reactivity Score
LONGITUDINAL, THREE TIME POINTS (BASELINE, 3-MONTH FOLLOW-UP, 6-MONTH FOLLOW-UP)
Stress Reactivity Survey Item collected via smart-phone delivered ecological momentary assessment
LONGITUDINAL, THREE TIME POINTS (BASELINE, 3-MONTH FOLLOW-UP, 6-MONTH FOLLOW-UP)

Who is running the study

Principal Investigator
E. L. B.
Emily L. Belleau, Principal Investigator
Mclean Hospital

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for melancholia?

There was evidence to suggest that antidepressants, such as fluoxetine, may be effective as antidepressants for treating melancholia. It is important that the patient is fully aware of this side effect, so they receive the required care, and so the therapist has the skills to manage this side effect.

Anonymous Patient Answer

What are the signs of melancholia?

Moods can be affected by many factors, but mood is also a part of the clinical picture of psychiatric conditions such as depression and schizophrenia that can worsen psychiatric symptoms. Melancholia as one such manifestation can be treated with antidepressants or tranquillizers if appropriate. It appears especially when depressive mood worsens or can cause social or occupational dysfunction or the loss of interest in activities to which one previously found pleasure.

Anonymous Patient Answer

What is melancholia?

The word'melancholia' comes from the Greek'melas', meaning black, and 'chroma', meaning color, for black-purplish-blue, and means 'dark mood'. Melancholia implies negative emotions in melancholic patients who do not experience excessive bodily or cognitive arousal, but exhibit a strong subjective sense of sadness that does not improve with the administration of mood-stabilizing agents.

Anonymous Patient Answer

Can melancholia be cured?

In some cases, the most effective therapy seems to be a non-pharmacological approach. In contrast, pharmacological treatments such as the use of antidepressants, lithium, and benzodiazepines have a minimal effect. These data highlight the complexity of the psychiatric spectrum and show that further research should strive to understand this topic more thoroughly.

Anonymous Patient Answer

What causes melancholia?

Because of the limited evidence base, there is no conclusive scientific evidence that the brain monoamine hypothesis represents a good explanation for depression. However, the brain monoamine hypothesis is highly plausible and warrants further attention.

Anonymous Patient Answer

How many people get melancholia a year in the United States?

If the DSM-II criteria are used to classify a depressive episode, a large number of non-fatal, recurrent episodes are diagnosed annually in the U.S. The authors argue that there needs to be a clear definition that can be used to monitor the course of melancholia.

Anonymous Patient Answer

How serious can melancholia be?

Compared to melancholia in depressive disorder, depressive episodes manifest more threatening features. The differences, especially between melancholia in depression and melancholia in a general population, indicate the need for adequate treatment guidelines and specific criteria.

Anonymous Patient Answer

Does computer task manipulation improve quality of life for those with melancholia?

Recent findings shows computer task manipulation has an acceptable impact on QOL in patients with melancholia. Further study of computerized cognitive tasks may reveal additional functions that may be beneficial.

Anonymous Patient Answer

How does computer task manipulation work?

In contrast to the results of some previous fMRI literature, this study provides evidence both that depressive symptoms may contribute to diminished brain activity during the performance of the task and that brain activity may contribute to depressive symptoms, suggesting that the relationship is bidirectional.

Anonymous Patient Answer

What does computer task manipulation usually treat?

Results from a recent clinical trial provides support for the utility of a computer intervention in the treatment of mood disorders and provides a clear avenue for future research.

Anonymous Patient Answer

What is the average age someone gets melancholia?

The average age when someone gets melancholia is around 50 – which is the same age when most people get bipolar spectrum disorder (which is currently thought to be a mood disorder). This suggests that if BD occurs earlier in life than is commonly believed, then those more likely have it in their late teens or 20s.\n

Anonymous Patient Answer

Have there been any new discoveries for treating melancholia?

Melancholia has been a medical challenge for thousands of years. [Practical suggestions for treating melancholia based on a more effective understanding of our current understanding and treatment are discussed with examples of the use of medications and treatments from ancient Greece and Rome through the first half of the 20th century to illustrate these principles] More research is needed to understand the physiology of melancholy and the neural correlates of symptoms in melancholia. More research is needed to identify the neurobiological causes of anxiety, depression, and irritability. More research is needed to refine diagnosis criteria for depressive disorders including melancholia as well as to help us understand the neural bases of depression.

Anonymous Patient Answer
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