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Behavioral Intervention

Positive affect treatment for Depression (PAT4ELA Trial)

N/A

Recruiting

Led By Kate R Kuhlman

Research Sponsored by University of California, Irvine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Aged 12-16

Be younger than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 4 months / end of treatment

Awards & highlights

PAT4ELA Trial Summary

This trial aims to test a new therapy called Positive Affect Therapy (PAT) on adolescents who have experienced early life adversity (ELA). The goal is to see if PAT can increase positive emotions and

Who is the study for?

This trial is for adolescents who have faced two or more types of childhood adversity but do not currently suffer from major depressive disorder. It aims to help those at risk for depression due to early life challenges.Check my eligibility

What is being tested?

The study tests Positive Affect Treatment (PAT) on these youths, comparing a group receiving PAT with a waitlist control group. The goal is to see if PAT can boost positive feelings and reduce symptoms of depression over time.See study design

What are the potential side effects?

Since the intervention involves psychological treatment rather than medication, traditional physical side effects are not expected. Emotional discomfort during therapy sessions could occur.

PAT4ELA Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 12 and 16 years old.

PAT4ELA Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 4-months / end of treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~4-months / end of treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and 4-months / end of treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Positive affect

Secondary outcome measures

Inflammatory gene expression

Systemic inflammation - C-reactive protein (CRP)

depressive symptoms - anhedonia subscale

+1 more

PAT4ELA Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Positive affect treatmentExperimental Treatment1 Intervention

PAT is a 15-week cognitive-behavioral therapy that focuses on increasing reward motivation and sensitivity at the neural, behavioral, and affective levels of analysis. These observed effects occur through PAT's effects on reward sensitivity and positive affect. Participants will be assigned to a therapist with training in cognitive-behavioral therapy who will meet with them weekly via telehealth.

Group II: WaitlistActive Control1 Intervention

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, IrvineLead Sponsor

544 Previous Clinical Trials

1,923,021 Total Patients Enrolled

8 Trials studying Depression

6,650 Patients Enrolled for Depression

Kate R KuhlmanPrincipal InvestigatorUC Irvine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available vacancies for potential participants in this research study?

"This research project is currently seeking eligible participants as stated on clinicaltrials.gov. The trial was initially uploaded to the platform on February 3, 2024, and last revised on February 15 of the same year."

Answered by AI

What is the current number of patients undergoing treatment in this medical study?

"Indeed, the details on clinicaltrials.gov highlight that this particular research study is currently in search of suitable participants. First registered on February 3rd, 2024, and last modified on February 15th, 2024, the trial aims to recruit a total of 22 individuals from one designated site."

Answered by AI