Fasting Mimicking Diet for Ulcerative Colitis
Trial Summary
What is the purpose of this trial?
This trial is testing a special diet that mimics fasting in people with mild to moderate Ulcerative Colitis. The diet allows people to eat certain safe foods while getting the benefits of fasting. Researchers want to see if this diet can reduce inflammation and improve quality of life for these patients.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop your current medications, but it excludes people taking medications that may not be safe with a calorie-restricted diet. It's best to discuss with your doctor if your medications fall into this category.
What data supports the effectiveness of the Fasting Mimicking Diet treatment for Ulcerative Colitis?
Research on mice has shown that a fasting-mimicking diet can reduce inflammation and help repair the intestines in inflammatory bowel disease, which is similar to ulcerative colitis. Additionally, a case study of a patient with ulcerative colitis found that intermittent fasting reduced inflammation markers and improved symptoms.12345
Is the Fasting Mimicking Diet safe for humans?
How does the Fasting Mimicking Diet treatment differ from other treatments for ulcerative colitis?
The Fasting Mimicking Diet (FMD) is unique because it involves cycles of reduced calorie intake that mimic fasting, which can reduce inflammation and promote intestinal repair, unlike traditional treatments that may not focus on dietary interventions. This approach has shown promise in reducing inflammation markers and improving gut health in both animal models and early human trials.12348
Research Team
Sidhartha R Sinha, MD
Principal Investigator
Stanford University
Eligibility Criteria
Adults aged 18-70 with mild to moderate Ulcerative Colitis can join this study. They must not be underweight, pregnant, or nursing and should have no history of significant heart disease, liver or kidney disorders, severe illness, recent weakening medical procedures, or specific dietary restrictions including nut allergies.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo three cycles of a 5-day fasting mimicking diet, administered once a month, followed by a regular diet for the rest of the month
Follow-up
Participants are monitored for changes in inflammatory markers and quality of life after completing the treatment cycles
Treatment Details
Interventions
- Fasting Mimicking Diet (Other)
- Regular Diet (Other)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Stanford University
Lead Sponsor
Dr. Richard A. Miller
Stanford University
Chief Executive Officer since 2023
Stanford University, MD
Dr. Robert Schott
Stanford University
Chief Medical Officer since 2021
University of Michigan, MD