Grapes for Crohn's Disease
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop your current medications, but you must not have changed your IBD medication in the past 4 weeks and should not have used probiotics or antibiotics in the last 14 days.
What evidence supports the effectiveness of the treatment for Crohn's Disease?
Research suggests that grape juice, which contains similar phenolic compounds to those in freeze-dried grape powder, has anti-inflammatory effects in experimental colitis, a condition similar to Crohn's Disease. This indicates potential benefits of grape-derived treatments in reducing inflammation.12345
Is freeze-dried grape powder safe for human use?
How does freeze-dried grape powder treatment for Crohn's disease differ from other treatments?
Freeze-dried grape powder is unique because it uses natural compounds found in grapes, like catechin and resveratrol, which are thought to have health benefits. Unlike traditional medications, this treatment is derived from food and focuses on leveraging the antioxidant properties of grapes to potentially help manage Crohn's disease.4791011
What is the purpose of this trial?
The overall objective of this pilot intervention study is to determine the impact of grape powder (46g/day freeze dried whole grape powder provided by the California Table Grape Commission) on the gut microbiotacomposition in adult patients with the IBD subtype Crohn's disease (CD).
Research Team
Abigail Basson, PhD
Principal Investigator
Case Western Reserve University
Eligibility Criteria
This trial is for adults who can consent to participate, are able to take oral nutrition, complete daily surveys, and record their meals. They must have a confirmed diagnosis of Crohn's disease but currently be in remission as indicated by a Harvey Bradshaw index score of less than 5.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline
Participants remove all grapes and berries from their diet
Intervention
Participants are supplemented with 46g/day freeze-dried grape powder
Follow-up
Participants are monitored for changes in gut microbiota composition and inflammation markers
Treatment Details
Interventions
- Freeze dried grape powder
Find a Clinic Near You
Who Is Running the Clinical Trial?
Case Western Reserve University
Lead Sponsor
California Table Grape Commission
Collaborator