AP-Brain for Cognitive Functioning
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests the safety and effectiveness of AP-Brain, a supplement with hydrolyzed collagen, for improving memory in middle-aged and older adults. Participants will take varying doses of AP-Brain or a placebo to assess its impact on cognitive function. It is suitable for individuals aged 40-79 who have noticed memory problems but do not have dementia or other major cognitive issues. Participants must maintain their lifestyle habits and avoid certain activities, such as high caffeine intake and intense exercise, before study visits.
As an unphased trial, this study allows participants to contribute to groundbreaking research on memory improvement.
Will I have to stop taking my current medications?
The trial does not specify if you must stop taking your current medications, but it does require you to maintain your current lifestyle habits, including medications, as much as possible. However, if your medications might impact the study's safety or effectiveness, you may need to adjust them.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that AP-Brain, which contains a type of processed protein called hydrolyzed collagen, is generally safe for people. One study found that this kind of collagen, like the one in AP-Brain, did not cause any adverse side effects, indicating that many people can use it without issues. Another study also found that hydrolyzed collagen is safe and easily processed by the body. These findings are encouraging for those considering joining the trial. However, since individual responses can vary, consulting a doctor before deciding to participate is advisable.12345
Why are researchers excited about this trial?
Most treatments for cognitive decline focus on neurotransmitter balance, like those that increase acetylcholine levels. However, AP-Brain is unique because it uses hydrolyzed collagen, a completely different approach. Researchers are excited because collagen could offer a novel way to support brain health and cognitive function. Unlike neurotransmitter-focused treatments, AP-Brain's various doses (1g, 3g, and 5g) might provide flexible options for different needs. This represents a fresh perspective on enhancing cognitive health, potentially offering benefits through collagen's impact on brain structure and support.
What evidence suggests that AP-Brain might be an effective treatment for cognitive function?
Studies have shown that collagen hydrolysates, a type of protein, can positively affect brain function. One clinical study indicated that taking 5 grams of collagen peptides daily improved memory and thinking skills. Another study found changes in brain structure and language skills after consuming collagen hydrolysates. Participants also reported feeling more alert and energetic. These findings suggest that AP-Brain, which contains hydrolyzed collagen, might help improve memory and thinking abilities.36789
Who Is on the Research Team?
David Crowley
Principal Investigator
KGK Science Inc.
Are You a Good Fit for This Trial?
This trial is for healthy adults aged 40-79 with self-reported memory issues. Women must be non-childbearing, either post-menopausal, sterilized, or using reliable contraception. Men should have a vasectomized partner or agree to use contraception.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume AP-Brain at 1 g, 3 g, or 5 g, or Placebo and complete memory assessment questionnaires
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- AP-Brain
Trial Overview
The trial tests AP-Brain's effects on cognitive function at doses of 1g, 3g, and 5g compared to a placebo in middle-aged and older adults with memory complaints. Participants will take the supplement and complete memory assessments.
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
Placebo Group
AP-Brain (5 g) contains 5 g of hydrolyzed collagen in a capsule
AP-Brain (3 g) contains 3 g of hydrolyzed collagen in a capsule
AP-Brain (1g) contains 1 g of hydrolyzed collagen in a capsule
Placebo consists of Silicified Microcrystalline Cellulose, magnesium stearate, Hydroxypropyl cellulose, and titanium dioxide
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rousselot BVBA
Lead Sponsor
KGK Science Inc.
Industry Sponsor
Najla Guthrie
KGK Science Inc.
Chief Executive Officer since 1997
Research career at the Centre for Human Nutrition, University of Western Ontario
Dr. Bibiane Zakaria
KGK Science Inc.
Chief Medical Officer since 2023
MD from an unspecified institution
Citations
Effects of Collagen Hydrolysates on Human Brain Structure ...
Daily ingestion of CH changed brain structure and improved language cognitive function. Keywords: collagen hydrolysate, cognitive health, magnetic resonance ...
2.
researchgate.net
researchgate.net/publication/338141617_Effects_of_Collagen_Hydrolysates_on_Human_Brain_Structure_and_Cognitive_Function_A_Pilot_Clinical_Study(PDF) Effects of Collagen Hydrolysates on Human Brain ...
This study investigated the effects of collagen hydrolysates (CH) on language cognitive function and brain structure.
Collagen peptides supplementation improves function, ...
In a clinical pilot study, Koizumi et al., (2019) found that CP supplementation of 5 g/d for 4 weeks improved cognitive function and memory, as ...
4.
auctoresonline.com
auctoresonline.com/article/effects-of-a-jellyfish-collagen-based-amino-acid-supplement-on-cognitive-function-and-memory-a-pilot-investigationEffects of a Jellyfish Collagen-Based Amino Acid ...
Though not analyzable, over half the individuals throughout the study period voluntarily reported positive outcomes, especially related to alertness, energy, ...
Collagen peptide supplementation before bedtime reduces ...
CP supplementation did not influence sleep quantity, latency, or efficiency, but reduced awakenings and improved cognitive function in physically active males ...
A Clinical Trial to Investigate the Safety and Efficacy of AP ...
The goal of this clinical trial is to investigate the safety and efficacy of AP-Brain on cognitive function at varying dosages in healthy ...
AP-Brain for Cognitive Functioning · Info for Participants
The goal of this clinical trial is to safety and efficacy of AP-Brain on cognitive function at varying dosages in healthy middle-aged and ...
The Efficacy and Safety of CollaSel Pro® Hydrolyzed ...
Accordingly, CollaSel Pro® hydrolyzed collagen peptide can be considered a well-tolerated, safe product that effectively improves dermal health ...
9.
certifiednutra.com
certifiednutra.com/wp-content/uploads/2025/06/J-of-Clinical-Research-and-Reports_May-2025.pdfJournal ofClinical Research and Reports AUCTORES
Importantly, no adverse side effects were reported, suggesting the supplement could be safely used by a large segment of the global population.
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