High-Fiber Plant-Based Diet for Clonal Hematopoiesis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether a high-fiber, plant-based diet can improve the quality of life for individuals with clonal hematopoiesis (CH), a condition where blood cells develop mutations. Participants will either follow this diet with support from a dietitian or continue with their usual care. The trial focuses on how dietary changes may affect day-to-day well-being, tracked through surveys. Ideal participants have CH confirmed through specific tests, a body mass index (BMI) of 25 or higher, consume less than 30 grams of fiber daily, and are open to trying new recipes. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research on diet and well-being.
Do I have to stop taking my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications. However, if you are on GLP-1 drugs, you can participate if you've been on a stable dose for at least 3 months.
What prior data suggests that a high-fiber plant-based diet is safe for people with clonal hematopoiesis?
Research has shown that a high-fiber plant-based diet (HFPBD) is generally safe for people. Studies have found that this diet is easy to follow and can improve health in several ways. For example, one study found that the HFPBD was safe and practical, enhancing diet quality and gut health over 12 weeks. Another study noted that this diet boosted metabolism and immune function without causing serious side effects.
These findings suggest that following an HFPBD could safely improve quality of life, especially for those with certain health conditions. However, consulting a healthcare provider before making any dietary changes is always important to ensure they suit individual health needs.12345Why are researchers excited about this trial?
Unlike the standard of care for clonal hematopoiesis, which often involves monitoring and lifestyle advice, the high-fiber plant-based diet offers a fresh approach. This diet is unique because it aims to improve health by increasing fiber intake through plant-based meals, potentially impacting blood health and reducing the progression of clonal hematopoiesis. Researchers are excited because this diet focuses on a non-invasive, nutrition-based intervention that could enhance overall well-being and provide a novel way to manage this condition.
What evidence suggests that a high-fiber plant-based diet could improve quality of life for people with clonal hematopoiesis?
This trial will compare a high-fiber, plant-based diet with usual care for participants with clonal hematopoiesis. Studies have shown that such a diet can benefit health. Research suggests it might improve key health indicators related to metabolism and the immune system. High-fiber diets have been linked to slower progression of diseases related to blood disorders, like multiple myeloma. Evidence also indicates that these diets can reduce risk factors for heart disease, enhancing overall well-being. For individuals with clonal hematopoiesis, these potential benefits suggest that a high-fiber, plant-based diet could improve quality of life.34567
Who Is on the Research Team?
Urvi Shah, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Are You a Good Fit for This Trial?
This trial is for people diagnosed with clonal hematopoiesis (CH). Participants should be able to follow a plant-based diet and complete surveys. Specific inclusion or exclusion details are not provided.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a high-fiber plant-based diet with regular phone or video calls with a dietitian
Follow-up
Participants are monitored for quality of life improvements using questionnaires/surveys
What Are the Treatments Tested in This Trial?
Interventions
- High-Fiber Plant-Based Diet
Trial Overview
The study tests if eating a high-fiber, plant-based diet—possibly with supplements and fermented foods—can improve quality of life in people with CH. Quality of life will be measured using questionnaires.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants will have a phone call or video call with a dietitian every 2 weeks for the first 12 weeks, every 4 weeks from Weeks 13-24, and every 8 weeks from Weeks 25-52. Participants will receive high-fiber plant-based meals for 12 weeks
Participants will have phone calls with a member of the study team every 4 weeks for the first 12 weeks. After the first 12 weeks, participants will have a phone call or video call with a dietitian at Weeks 13 and 53 (end of study).
Find a Clinic Near You
Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor
Citations
Association of Diet Quality With Prevalence of Clonal ... - PMC
The results of this study suggest that unhealthy eating habits may be associated with the development of clonal hematopoiesis of indeterminate potential.
A Dietary Study for People With Clonal Hematopoiesis
The researchers are doing this study to find out whether a high-fiber plant-based diet (HFPBD) can improve quality of life for people with ...
3.
aacrjournals.org
aacrjournals.org/cancerdiscovery/article/16/4/697/775559/A-High-Fiber-Plant-Based-Diet-in-Myeloma-PrecursorA High-Fiber, Plant-Based Diet in Myeloma Precursor Disorders
A high-fiber, plant-based diet improved metabolic, microbiome, and immune biomarkers in patients with MGUS/SMM and delayed myeloma progression in mouse.
A Dietary Study for People With Clonal Hematopoiesis
The researchers are doing this study to find out whether a high-fiber plant-based diet (HFPBD) can improve quality of life for people with CH.
5.
oncologynewscentral.com
oncologynewscentral.com/multiple-myeloma/high-fiber-diet-tied-to-slower-multiple-myeloma-progression-better-transplant-outcomesHigh-Fiber Diet Tied to Slower Multiple Myeloma ...
High-fiber diets may play a role in hematologic malignancies, from slowing disease progression in precursor conditions of multiple myeloma ...
6.
news-medical.net
news-medical.net/news/20250602/High-fiber-plant-based-diet-could-benefit-patients-at-risk-for-developing-multiple-myeloma.aspxHigh-fiber plant-based diet could benefit patients at risk for ...
Results from a new clinical trial suggest that a high-fiber plant-based diet could benefit patients at risk for developing multiple myeloma.
High-Fiber Plant-Based Diet for Clonal Hematopoiesis
The study tests if eating a high-fiber, plant-based diet—possibly with supplements and fermented foods—can improve quality of life in people with CH. Quality of ...
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