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AZD5305 for Advanced Cancers (PETRA Trial)
PETRA Trial Summary
This trial is testing if a new cancer drug is safe and effective.
PETRA Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowPETRA Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.PETRA Trial Design
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Who is running the clinical trial?
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- My heart condition meets the study's requirements.I haven't taken any experimental drugs recently.My organs and bone marrow are working well.I am 18 years old or older.I have had severe low blood counts for more than 2 weeks.I am currently receiving or have recently received radiotherapy.My advanced cancer is confirmed and deemed suitable for this study.I haven't taken nitrosourea or mitomycin C in the last 6 weeks.I haven't had major surgery in the last 4 weeks.My cancer is confirmed and considered suitable for this study's treatment.I have had one prior treatment with a PARPi-based regimen.I don't need high-dose steroids for brain or spinal cancer symptoms, and my condition is stable.I have a condition that increases my risk of bleeding.I have had serious heart or stroke issues in the last 6 months.I have been diagnosed with myelodysplastic syndrome or acute myeloid leukemia.I have never been treated with PARPi-based therapy.I cannot take pills due to severe nausea, vomiting, or past major gut surgery.I am not taking any strong or moderate drugs or supplements that affect liver enzymes.I have not received a live vaccine within the last 28 days.I haven't had cancer treatment in the last 3 weeks.You are expected to live for at least 12 weeks.My cancer is getting worse.I can take care of myself and am up and about more than half of the day.I can provide a sample of my tumor for testing, if it's available.I have a history of cancer that may affect the study's safety or results.I am on more than 10 mg of prednisone or its equivalent daily.I am not taking medication that affects heart rhythm.
- Group 1: Module 6 AZD5305 + Camizestrant
- Group 2: Module 1: AZD5305 Monotherapy
- Group 3: Module 2: AZD5305 + Paclitaxel
- Group 4: Module 3: AZD5305 + Carboplatin with or without Paclitaxel
- Group 5: Module 4: AZD5305 + Trastuzumab Deruxtecan
- Group 6: Module 5 AZD5305 + Datopotamab Deruxtecan
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What other research projects have used AZD5305?
"City of Hope Comprehensive Cancer Center first began studying AZD5305 in 1997 and, as of now, 1549 trials have been completed. Out of the 1229 active studies, a significant portion are taking place in San Francisco, California."
Are elderly people eligible to participate in this clinical trial?
"This particular trial is seeking patients that fall between 18-130 years of age, which excludes both children and seniors. In total, there are 330 clinical trials for minors and 7887 for older adults."
Who qualifies to enroll in this clinical trial and receive the experimental medication?
"This study is looking for 715 individuals with breast cancer that meet the following age, health, and previous treatment criteria: 18-130 years old, Eastern Cooperative Oncology Group Performance status of 0-2, a life expectancy of 12 weeks or more, progressive cancer not responding to prior treatments (up to one line of PARPi-based therapy), and adequate organ and marrow function. For Part B expansion cohorts, FFPE tumour specimens are mandatory where available."
Are patients still being accepted into this clinical trial?
"Yes, according to the most recent update on clinicaltrials.gov, this trial is still looking for patients. The study was first posted on November 12th 2020 and was last edited on October 31st 2022. In total, 8 different sites are recruiting 715 participants."
How many research subjects are being recruited for this investigation?
"That is correct, the online information from clinicaltrials.gov does show that this study is looking for more participants. The trial was advertised on 11/12/2020 and has since been edited on 10/31/2022. They are searching for 715 people to join across 8 locations."
Is this clinical trial taking place in numerous hospitals throughout Canada?
"To participate in this study, it is important to choose a location that is close to you from the 8 available sites. The locations include major cities such as San Francisco and Montreal, as well as more rural areas like Kelowna."
What is the main goal that researchers are hoping to achieve with this trial?
"The aim of the trial, which will last until the end of the first cycle, is to track adverse events and serious adverse events. Additionally, researchers are looking at objective response rate for prostate cancer patients and the time it takes to reach maximum concentration (Tmax) and maximum plasma concentration (Cmax)."
Who else is applying?
What site did they apply to?
What portion of applicants met pre-screening criteria?
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