7T MRI Scan for Brain Cancer

JJ
MW
Overseen ByMax Wintermark
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: M.D. Anderson Cancer Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new type of MRI scan, called 7T MRI (7 Tesla Magnetic Resonance Imaging), to determine if it can capture clearer images of brain tumors. The goal is to help doctors better identify and understand brain tumors and track patient responses to treatments. Individuals who have recently discovered a brain tumor or have been treated for one and are seeing new signs on an MRI suggesting recurrence may be suitable for this trial. As an unphased study, this trial offers a unique opportunity to contribute to advancing imaging technology that could enhance brain tumor diagnosis and monitoring.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that the 7T MRI scan is safe for imaging central nervous system tumors?

Research has shown that 7 Tesla (7T) MRI is a promising tool for brain imaging. Studies indicate that it can reveal details in the brain that standard MRI machines cannot detect. This advanced imaging can help doctors better understand and manage complex brain disorders.

Regarding safety, other clinical trials have used 7T MRI without major problems. There are no significant reports of harmful effects from undergoing a 7T MRI scan, suggesting that it is generally well-tolerated by patients. MRI uses strong magnets and radio waves, which are considered safe and do not involve radiation.

For those considering joining a trial involving 7T MRI, existing research and past trials suggest that it is a safe procedure.12345

Why are researchers excited about this trial?

Researchers are excited about using 7 Tesla MRI for brain cancer because it offers much clearer and more detailed images than standard MRIs. Unlike traditional MRI machines that usually operate at 1.5 to 3 Tesla, the 7T MRI provides higher resolution pictures, which can help doctors pinpoint tumors with greater accuracy. This could lead to better diagnosis and treatment planning, potentially improving outcomes for patients with brain cancer.

What evidence suggests that the 7T MRI is effective for imaging brain cancer?

Studies have shown that 7 Tesla (7T) MRI scans are 31% more effective at diagnosing than standard MRI machines. In this trial, participants will undergo a 7T MRI, which provides clearer and more detailed images, aiding doctors in accurately identifying brain tumors. This enhanced clarity can reveal small lesions that regular MRIs might miss, offering better contrast and detail. Research also indicates that 7T MRI helps doctors understand a tumor's position relative to important nerves, which is crucial for surgical planning. Overall, 7T MRI serves as a powerful tool for diagnosing and managing brain tumors effectively.13678

Who Is on the Research Team?

MW

Max Wintermark

Principal Investigator

M.D. Anderson Cancer Center

Are You a Good Fit for This Trial?

This trial is for adults with new or suspected recurrent central nervous system tumors, including gliomas and metastases. Participants may have had previous treatments like surgery or chemotherapy. They must have a tumor of at least 5mm that's visible on an MRI scan and not be pregnant, claustrophobic, allergic to contrast agents used in MRIs, or have renal failure.

Inclusion Criteria

I have a newly diagnosed brain tumor or cancer spread to the brain that is at least 5 mm.
My doctors suspect my cancer has returned and agree it looks like it's recurring.
Experts agree I likely have a brain tumor or cancer spread to the brain.
See 2 more

Exclusion Criteria

You are unable to have a magnetic resonance imaging (MRI) scan for medical reasons.
You have certain types of implants or medical devices that can't be used with MRI machines, or you have conditions like pregnancy, kidney problems, or claustrophobia that can make getting an MRI unsafe for you.
You have metal objects inside your body that could be unsafe during an MRI scan.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Diagnostic Imaging

Participants undergo 7T MRI to assess imaging quality and contrast-to-noise ratio

1 day
1 visit (in-person)

Follow-up

Participants are monitored for imaging outcomes and patient satisfaction

1 year

What Are the Treatments Tested in This Trial?

Interventions

  • 7 Tesla Magnetic Resonance Imaging
Trial Overview The study is testing the effectiveness of a high-resolution 7T MRI scan compared to standard MRI scans in detecting and monitoring brain tumors. It aims to determine if the newer technology provides clearer images for better diagnosis and treatment evaluation.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Diagnostic (7T MRI)Experimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

M.D. Anderson Cancer Center

Lead Sponsor

Trials
3,107
Recruited
1,813,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

Citations

Clinical 7 Tesla magnetic resonance imaging - PubMed CentralA pooled analysis reported a 31% diagnostic gain with 7 T MRI over conventional field strengths [11]. The increased signal‐to‐noise ratio at 7 T ...
Ultra-High-Field MRI in the Diagnosis and Management ...Current literature generally supports greater resolution imaging from 7T compared to 1.5T or 3T MRI, improving visualization of cerebral ...
7T MRI Scan for the Early Detection of Melanoma Brain ...This clinical trial studies the use of 7-Tesla (7T) magnetic resonance imaging (MRI) in detecting melanoma that has spread to the brain (melanoma brain ...
Utility of ultra‐high‐field magnetic resonance imaging in ...Conventional MRI may miss subtle lesions, and 7T provides unprecedented anatomical details with high spatial resolution and improved contrast.
New Study Investigates 7-Tesla MRI's Ability to Visualize ...The 7-Tesla MRI gives physicians the ability to visualize the relationship of the tumor to cochlear and cranial nerves, thus allowing them to preserve hearing ...
7T MRI Scan for the Early Detection of Melanoma Brain ...This clinical trial studies the use of 7-Tesla (7T) magnetic resonance imaging (MRI) in detecting melanoma that has spread to the brain (melanoma brain ...
Towards clinical translation of 7 Tesla MRI in the human ...7T MRI offers unique benefits over lower field strength for clinical neuro-imaging. 7T can allow detection of clinical features not visible at 3T.
7 Tesla magnetic resonance spectroscopic imaging predicting ...We successfully classified IDH mutation status and high- versus low-grade gliomas preoperatively based on 7 T MRSI and clinical tumor segmentation.
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