Imaging for Cardiovascular Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines whether changes in the tiny blood vessels in the eyes can indicate the severity of heart disease. It employs a special eye scan called Swept Source Optical Coherence Tomography Angiography (SS-OCTA) to assess these blood vessels and compares the findings to results from a common heart test. The trial seeks participants who have undergone a standard heart scan and do not have eye diseases such as glaucoma or macular degeneration. Individuals who have experienced a stroke or sudden vision loss are ineligible. Participants should be comfortable with an eye exam. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could enhance heart disease diagnosis.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that this imaging technique is safe?
Research has shown that Swept Source Optical Coherence Tomography Angiography (SS-OCTA) is a safe imaging tool. Studies have found that SS-OCTA is non-invasive, as it does not involve surgery or entering the body. By using light to capture detailed images of blood vessels, it reduces the risk of complications.
In one study involving 337 eyes, SS-OCTA was used without causing significant side effects, indicating it is well-tolerated by patients. Another study confirmed that optical coherence tomography (OCT) imaging, similar to SS-OCTA, is reliable and safe for examining blood vessels.
Overall, current research considers SS-OCTA safe. It provides a clear view of blood vessels without major risks.12345Why are researchers excited about this trial?
Swept Source Optical Coherence Tomography Angiography (SS-OCTA) is unique because it offers a non-invasive way to visualize blood vessels with remarkable detail, unlike traditional methods like angiography that require contrast dye and radiation. Researchers are excited about SS-OCTA because it can provide high-resolution images of the cardiovascular system, potentially allowing for earlier and more accurate detection of vascular issues. This advanced imaging technique also reduces patient risk and discomfort by eliminating the need for invasive procedures.
What evidence suggests that this imaging technique is effective for cardiovascular disease?
Research shows that Swept Source Optical Coherence Tomography Angiography (SS-OCTA), which all participants in this trial will receive, clearly displays details about the blood vessels in the eye. Studies have found links between changes in these eye vessels and heart health. SS-OCTA provides sharp, detailed images that aid in understanding the condition of the heart and blood vessels. Previous research has shown it to be a reliable and consistent method for examining heart-related issues. Overall, SS-OCTA holds promise in connecting eye health to heart health through advanced imaging techniques.13678
Who Is on the Research Team?
Rukhsana Mirza, MD
Principal Investigator
Northwestern University
Are You a Good Fit for This Trial?
This trial is for adults aged 18-80 who are being checked for heart disease and can undergo a clinical eye exam. They must be able to consent, not have any known eye diseases except for needing glasses or contacts, and should be getting standard carotid artery scans.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging and Assessment
Participants undergo SS-OCTA, color fundus photography, and retinal exams to assess retinal vasculature and correlate with cardiovascular disease
Follow-up
Participants are monitored for any changes in retinal vasculature and cardiovascular health
What Are the Treatments Tested in This Trial?
Interventions
- Swept Source Optical Coherence Tomography Angiography
Trial Overview
The study is testing if a special type of eye scan called SS-OCTA can show changes in the tiny blood vessels of the retina that match up with how severe someone's heart disease is, as seen on neck artery ultrasounds.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
50 participants identified in the Northwestern Medicine Division of Vascular Surgery.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northwestern University
Lead Sponsor
Citations
Artificial intelligence-based prediction of ...
The value of swept-source retinal optical coherence tomography–angiography (SS OCT-A) imaging is significantly enhanced by image analysis tools ...
Optical coherence tomography angiography quantitative ...
PURPOSE The aim of our study was to analyze the association between different cardiovascular risk scores and swept-source optical coherence ...
A Retinal Oct-Angiography and Cardiovascular STAtus ...
Optical coherence tomography angiography (OCT-A), as a window into the state of the cardiovascular system, is a rapid, reliable, and reproducible imaging ...
The Role of Optical Coherence Tomography in Coronary ...
OCT is an optical analog of intravascular ultrasound (IVUS) that can be used to examine the coronary arteries and has 10-fold higher resolution than IVUS.
Efficacy and Safety of High-Frequency Optical Coherence ...
In this multicenter, single-arm study, we evaluated the efficacy and safety of a novel imaging catheter and system called high-frequency optical coherence ...
Intracoronary Optical Coherence Tomography - PubMed Central
OCT is a catheter-based invasive imaging system. Using light rather than ultrasound, OCT produces high-resolution in vivo images of coronary arteries and ...
Swept-Source OCT Angiography-Derived Regional Normative ...
Methods: This study included 337 eyes without significant fundus abnormalities or systemic conditions affecting blood flow. Swept-source optical coherence ...
Phase stable swept-source optical coherence tomography ...
Swept-source optical coherence tomography (SS-OCT) is an imaging tool capable of providing three-dimensional information of biological tissues ...
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