Imaging for Cardiovascular Disease

Overseen By Arnold Nadel

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Northwestern University

Disqualifiers: Ophthalmologic disease, Stroke, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

50 Participants Needed

Trial Summary

What is the purpose of this trial?

This study aims to determine whether changes in retinal vasculature seen on SS-OCTA can be correlated to degree of cardiovascular disease as measured by carotid duplex ultrasonography.

Research Team

Rukhsana Mirza, MD

Principal Investigator

Northwestern University

Eligibility Criteria

This trial is for adults aged 18-80 who are being checked for heart disease and can undergo a clinical eye exam. They must be able to consent, not have any known eye diseases except for needing glasses or contacts, and should be getting standard carotid artery scans.

Inclusion Criteria

Able to participate in a clinical eye examination setting.

Subjects receiving standard of care carotid duplex ultrasounds.

Able to consent.

Exclusion Criteria

You have had a stroke or sudden loss of vision in the past.

Lack of capacity to provide informed consent.

You can't have an eye examination as required for the clinical trial.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Imaging and Assessment

Participants undergo SS-OCTA, color fundus photography, and retinal exams to assess retinal vasculature and correlate with cardiovascular disease

2 hours

1 visit (in-person)

Follow-up

Participants are monitored for any changes in retinal vasculature and cardiovascular health

4 weeks

Treatment Details

Interventions

• Swept Source Optical Coherence Tomography Angiography

Trial Overview The study is testing if a special type of eye scan called SS-OCTA can show changes in the tiny blood vessels of the retina that match up with how severe someone's heart disease is, as seen on neck artery ultrasounds.

Participant Groups

Group I: All Participants Experimental Treatment 1 Intervention

50 participants identified in the Northwestern Medicine Division of Vascular Surgery.

Who Is Running the Clinical Trial?

Northwestern University

Lead Sponsor

Trials

1,674

Recruited

989,000+