MRI for Lung Cancer

Overseen By Caitlin Eggleston, MPH

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Maryland, Baltimore

Disqualifiers: Pregnancy, Claustrophobia, MRI contraindications, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to assess a real time motion tracking of lung tumors and important organs next to the tumor while breathing during a participant's radiation treatment. This will be assessed through a four-dimensional magnetic resonance imaging (MRI) scan before starting your radiation treatment and x-ray fluoroscopy images that are taken during radiation

Who Is on the Research Team?

Amit Sawant, PhD

Principal Investigator

University of Maryland, Baltimore

Are You a Good Fit for This Trial?

This trial is for individuals with non-small cell lung cancer who are scheduled to undergo radiation therapy. Participants must be able to have an MRI scan and tolerate lying still for imaging before and during their treatment.

Inclusion Criteria

Patient has signed informed consent document and agreed to study procedures

I am to receive external beam radiation, possibly with other treatments like chemo or immunotherapy.

I have no limits on my radiation therapy in terms of sessions or where the cancer is.

Exclusion Criteria

I am not pregnant nor trying to get pregnant.

I experience pain when lying down or cannot raise my arm above my head while lying down.

Pre-existing contraindications for MRI, such as any MRI-conditional or MRI-unsafe foreign objects within the body, non-removable ear cochlear or eye implant, aneurysm clip, cardiac pacemaker/wires, internal defibrillator, tissue expander, recent stent placement, penile prosthesis, medication patch, artificial limb, pregnancy, and claustrophobia

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Imaging

Participants receive a 4D CT Simulation and a 4D MRI with surface monitoring at baseline

1 week

1 visit (in-person)

Radiation Treatment

Participants undergo radiation treatment with additional fluoroscopy imaging and surface monitoring

6-8 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• MRI

Trial Overview

The study is testing the use of four-dimensional MRI scans and x-ray fluoroscopy images to track lung tumors and nearby organs in real time as patients breathe during radiation treatments.

How Is the Trial Designed?

Group I: Imaging Experimental Treatment 1 Intervention

At baseline, patients will receive a 4D CT Simulation (standard of care) along with a 4D MRI with surface monitoring (research). During their radiation treatment, they will receive additional fluoroscopy imaging and surface monitoring.

Who Is Running the Clinical Trial?

University of Maryland, Baltimore

Lead Sponsor

Trials

729

Recruited

540,000+