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Antioxidant

Pomegranate Supplement for Burnout

N/A
Waitlist Available
Led By Joshua Mann, MD, MPH
Research Sponsored by University of Mississippi Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 4 weeks, 8 weeks
Awards & highlights

Study Summary

This trial will study whether pomegranate supplementation can help reduce stress and improve wellbeing in medical students and residents who often experience high rates of mental distress and burnout.

Who is the study for?
This trial is for first or second year medical students and residents at the University of Mississippi Medical Center. It's not suitable for those who are pregnant, planning to become pregnant, breastfeeding, taking chronic medications (other than contraception), using supplements, allergic to pomegranate or gelatin, or have severe depression or anxiety based on DASS-21 scores.Check my eligibility
What is being tested?
The study tests if Pomella pomegranate extract can reduce stress and improve well-being in medical trainees compared to a placebo. Participants will be randomly assigned to receive either the supplement or an inactive substance without knowing which one they're getting.See study design
What are the potential side effects?
Pomegranate extract may cause digestive discomfort or allergic reactions in some individuals. However, since it's a natural antioxidant supplement, serious side effects are less common compared to pharmaceutical drugs.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 4 weeks, 8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 4 weeks, 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in Scores on Maslach Burnout Inventory over time
Changes in fatigue as measured by the Iowa Fatigue Scale over time
Changes in health as measured by scores on the RAND Short-Form 12 over time
+1 more
Secondary outcome measures
Change in Serum total antioxidant capacity over time
Change in TREG cytokine levels from peripheral blood and culture supernatants over time
Change in Th1 cytokine levels from peripheral blood and culture supernatants
+5 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Pomegranate SupplementExperimental Treatment1 Intervention
Participants in this arm will take a capsule with 500 mg of "Pomella" pomegranate extract twice each day for 28 days.
Group II: PlaceboPlacebo Group1 Intervention
Participants in this arm will take a gelatin placebo capsule twice each day for 28 days.

Find a Location

Who is running the clinical trial?

University of Mississippi Medical CenterLead Sponsor
171 Previous Clinical Trials
194,965 Total Patients Enrolled
University of Rhode IslandOTHER
52 Previous Clinical Trials
22,271 Total Patients Enrolled
Joshua Mann, MD, MPHPrincipal InvestigatorUniversity of Mississippi Medical Center

Media Library

Pomella pomegranate extract (Antioxidant) Clinical Trial Eligibility Overview. Trial Name: NCT03063372 — N/A
Burnout Research Study Groups: Placebo, Pomegranate Supplement
Burnout Clinical Trial 2023: Pomella pomegranate extract Highlights & Side Effects. Trial Name: NCT03063372 — N/A
Pomella pomegranate extract (Antioxidant) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03063372 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this medical experiment accept those aged eighty or older as participants?

"The enrollment criteria for this trial is restricted to persons aged 21 and under 40."

Answered by AI

What criteria must be fulfilled for someone to participate in this experiment?

"The medical study is seeking 50 people between the ages of 21 and 40 who are currently suffering from burnout. However, to qualify for participation, these individuals must be either a first or second-year student at Mississippi Medical Center as well as first or second year residents in their respective fields."

Answered by AI

Are recruitment efforts underway for this clinical trial?

"Unfortunately, this research investigation is no longer recruiting patients. Initially listed on February 28th 2017, it was most recently updated March 31st 2021. There are still 130 other clinical trials actively seeking participants however."

Answered by AI

What are the chief goals of this experiment?

"The primary result this study is aiming to measure, over a baseline and two subsequent four week intervals, is the alteration in fatigue as measured by the Iowa Fatigue Scale. Additionally, changes in total serum oxidative stress levels, peripheral blood Th2 cytokine concentrations, and TREG cytokine densities from both PBMCs and culture supernatants will be considered secondary outcomes."

Answered by AI

Who else is applying?

What state do they live in?
Tennessee
How old are they?
18 - 65
What site did they apply to?
University of Mississippi Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
~5 spots leftby Feb 2025