Plasma Treatment for Acne/Rosacea

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: The Skin Center Dermatology Group

Disqualifiers: Specific condition

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 12 months

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new method for treating skin conditions like acne and rosacea using a special device that creates cold plasma, a gas with charged particles. The goal is to determine if this non-thermal plasma can help clear up skin issues. Two methods are under evaluation: one applies the plasma directly to the skin, and the other combines it with a medium to aid application. Individuals diagnosed with acne or rosacea who can follow the study steps might be suitable candidates for this trial. As an unphased trial, this study provides a unique opportunity to explore innovative treatments for skin conditions.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications.

What prior data suggests that this plasma device is safe for treating skin disorders?

Research has shown that both indirect and non-thermal atmospheric plasma treatments are generally safe for skin conditions. Studies have found that cold atmospheric plasma (CAP) is safe and effective, with only minor side effects. CAP is already used successfully for cleaning skin and aiding wound healing.

Some research suggests that higher power or longer plasma treatments may cause more skin side effects. However, these effects are usually minor and resolve quickly. Most side effects, such as skin irritation or damage, heal soon after treatment.

Overall, current studies indicate that plasma treatments are well-tolerated and safe when used correctly. ^{1 2 3 4 5}

Why are researchers excited about this trial's treatments?

Researchers are excited about non-thermal atmospheric plasma treatments for acne and rosacea because they offer a unique approach compared to traditional options like topical antibiotics or retinoids. Unlike these standard treatments, plasma therapy uses a non-invasive method that involves applying a cold plasma directly to the skin. This plasma generates reactive species that can kill bacteria and reduce inflammation without the side effects typically associated with conventional drugs. Additionally, the indirect non-thermal atmospheric plasma treatment combines plasma with a medium, potentially enhancing its effectiveness by improving penetration and targeting specific skin areas. This innovative mechanism of action and delivery method could provide faster and more targeted results for patients.

What evidence suggests that this plasma device is effective for treating acne and rosacea?

Research has shown that non-thermal atmospheric plasma (CAP) yields promising results in treating skin conditions like acne and rosacea. In this trial, participants will receive either non-thermal atmospheric plasma treatment or indirect non-thermal atmospheric plasma treatment. Studies have found that CAP reduces inflammation and improves skin health. It increases oxygen levels and blood flow in the skin, which are important for healing. CAP is also recognized for its safety and minimal side effects. In previous patients, CAP demonstrated positive effects in reducing symptoms of skin disorders, making it a promising option for those looking to improve their skin condition. ^{2 3 6 7 8}

Are You a Good Fit for This Trial?

This trial is for individuals with certain skin conditions like Molluscum Contagiosum, Bowen's Disease, warts, and various forms of keratosis and acne. Participants must be able to follow the study procedures. Specific exclusions depend on the individual's condition.

Inclusion Criteria

Ability to complete study protocol

I have been diagnosed with the specific condition required.

I have been diagnosed with the specific condition required.

Exclusion Criteria

This criterion is not specific enough to provide a simplified summary. Can you please provide more details or context?

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive non-thermal atmospheric plasma treatment for skin disorders

12 months

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Indirect non-thermal, atmospheric plasma
• Non-thermal, atmospheric plasma

Trial Overview The study is testing a device that uses cold atmospheric plasma to treat different skin disorders including lesions and acne. It also looks at using this technology indirectly to help with hair loss associated with these skin conditions.

How Is the Trial Designed?

Group I: Non-thermal atmospheric plasma treatment Experimental Treatment 1 Intervention

Device treatment

Group II: Indirect non-thermal atmospheric plasma treatment Experimental Treatment 1 Intervention

A compound of non-thermal atmospheric plasma and medium is used to treat the target by direct application or by on-site generation of the compound

Who Is Running the Clinical Trial?

The Skin Center Dermatology Group

Lead Sponsor

Trials

5

Recruited

170+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC10652650/

A Prospective Randomized Controlled Pilot Study to Assess ... CAP is well established for wound therapy and has shown promising results in the treatment of cancer, acne, psoriasis, and other immune-mediated skin diseases ...

2. researchgate.net researchgate.net/publication/372648234_A_Prospective_Randomized_Controlled_Pilot_Study_to_Assess_the_Response_and_Tolerability_of_Cold_Atmospheric_Plasma_for_Rosacea

(PDF) A Prospective Randomized Controlled Pilot Study to ... Among these new modalities, non-thermal plasma, also known as CAP, therapies have demonstrated promising results in reducing inflammation and ...

3. withpower.com withpower.com/trial/phase-bowens-disease-2016-6fb5e

Plasma Treatment for Acne/Rosacea · Info for Participants What is the purpose of this trial? This study examines the efficacy of a non-thermal, atmospheric plasma device in the treatment of skin disorders ...

4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC9314643/

Plasma Dermatology: Skin Therapy Using Cold Atmospheric ... Firstly, tissue oxygen saturation and blood flow both improved in a plasma duration-dependent manner. Secondly, skin pH decreased by 0.3 after ...

5. eurjmedres.biomedcentral.com eurjmedres.biomedcentral.com/articles/10.1186/s40001-024-02088-9

Cold atmospheric plasma (CAP): a revolutionary approach in ... CAP technology has emerged as a revolutionary therapeutic technology in dermatology, recognized for its safety, effectiveness, and minimal side effects.

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC5381889/

Safety aspects of atmospheric pressure helium plasma jet ... The direct and indirect skin damage could be observed up to 2 weeks post–treatment. Past this, the wound was healed due to the fast regeneration ...

7. sciencedirect.com sciencedirect.com/science/article/pii/S0891584920312776

The emerging potential of cold atmospheric plasma in skin ... Cold Atmospheric Plasmas are already used in skin disinfection and wound healing. •. Reactive Oxygen and Nitrogen Species play a key role in plasma biomedical ...

8. mdpi.com mdpi.com/1420-3049/26/9/2523

Direct and Indirect Bactericidal Effects of Cold Atmospheric ... This research investigated the low discharge voltage bactericidal potential of direct microplasma treatment in comparison with indirect plasma ...