Persona IQ for Total Knee Replacement

Enrolling by invitation at 5 trial locations
MD
EK
Overseen ByErik Kowalski, PhD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a new knee implant that uses smart technology to track recovery after surgery. The goal is to determine how effectively this implant relieves pain and restores function for those needing a knee replacement. Participants will use the mymobility app to send data, aiding doctors in understanding recovery patterns. This study suits individuals with a smartphone who are scheduled for a knee replacement with the Persona IQ system. As a Phase 3 trial, it represents the final step before FDA approval, offering participants the opportunity to contribute to the development of a potentially groundbreaking treatment.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinator or your doctor.

What prior data suggests that the Persona IQ The Smart Knee is safe?

Research shows that the Persona IQ Personalized Knee System is a new type of smart knee implant. The FDA has approved it for use in total knee replacement surgeries, indicating it has undergone careful safety testing in people. The implant contains sensors that monitor knee movement, enabling doctors to track recovery remotely.

As an approved device, it meets specific safety standards. Although sources do not detail specific side effects or problems, FDA approval suggests it is generally safe for patients. However, patients should always discuss any concerns with their healthcare provider to ensure it is the right choice.12345

Why are researchers excited about this trial?

Researchers are excited about the Persona IQ Personalized Knee System because it integrates advanced sensor technology directly into the knee implant. Unlike traditional knee replacements that primarily focus on structural support, Persona IQ provides real-time data on the knee's functionality, helping both patients and doctors monitor recovery and performance more closely. This innovative approach aims to improve post-surgery outcomes by offering personalized insights and potentially enhancing rehabilitation strategies.

What evidence suggests that the Persona IQ The Smart Knee is effective for post-operative recovery?

Studies have shown that the Persona IQ Knee implant, which participants in this trial may receive, is safe and effective, with positive results up to two years post-surgery. Sensors in the implant track key movement details, such as step count, knee range of motion, and walking speed. This data helps doctors assess knee performance and detect any issues early. Research also indicates that recipients report improved well-being and mobility after receiving the implant. Overall, this smart knee implant provides valuable information that can enhance recovery and knee function.16789

Who Is on the Research Team?

EO

Erin Osborn

Principal Investigator

Zimmer Biomet

Are You a Good Fit for This Trial?

Inclusion Criteria

The patient meets the prerequisites for a single or dual total knee arthroplasty, based on medical records and physical examination indicating considerable pain and disability due to osteoarthritis.
The patient is eligible for the Persona IQ Personalized Knee System, even without participating in a study.
You have access to a computer with USB connection and appropriate home internet service that is suitable for the platform.
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo primary total knee arthroplasty/replacement (TKA/TKR) and are monitored using the Persona IQ Personalized Knee System with mymobility platform

90 days
Regular remote monitoring and data collection

Follow-up

Participants are monitored for safety and effectiveness after treatment, with data collection continuing for up to 1 year

1 year
Periodic remote monitoring

Data Analysis and Reporting

Data collected is analyzed for clinical outcomes, patient satisfaction, and device usability

Ongoing

What Are the Treatments Tested in This Trial?

Interventions

  • Persona IQ
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Persona IQ CohortExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Zimmer Biomet

Lead Sponsor

Trials
383
Recruited
67,800+
Dr. Nitin Goyal profile image

Dr. Nitin Goyal

Zimmer Biomet

Chief Medical Officer since 2021

MD from Harvard Medical School

Ivan Tornos profile image

Ivan Tornos

Zimmer Biomet

Chief Executive Officer since 2023

MBA from the University of Miami School of Business, BBA in Finance and International Marketing and Management from the University of Georgia Terry College of Business

Citations

Persona IQ® – Zimmer Biomet | Remote Patient MonitoringPersona IQ is a first-to-world smart knee implant that captures patient-specific gait and range of motion metrics during the course of patient monitoring.
Study Details | NCT06089291 | Persona IQ Cohort StudyThe study objective is to assess the seven kinematic metrics (step count, functional knee ROM, tibial ROM, distance walked, walking speed, cadence and stride ...
Patient reported outcomes and implant survivorship after ...The Persona Knee implant is safe and effective and the clinical results up to two years after surgery are promising. PROMs results are very good ...
Patient reported outcomes do not correlate to functional ...130 patients (75 female) received Persona IQ TKA (Zimmer Biomet, Warsaw, IN, USA) which includes a stem extension with embedded accelerometer and gyroscope.
Zimmer Biomet's Persona IQ Smart KneeThe Smart Knee™ implant offers patients and their healthcare team real-time insight into the knee's performance, highlighting potential issues even before ...
Study Details | NCT06089291 | Persona IQ Cohort StudyThe study objective is to assess the seven kinematic metrics (step count, functional knee ROM, tibial ROM, distance walked, walking speed, cadence and stride ...
Smart Knee Implant (Persona IQ®) Pittsburgh, PAZimmer Biomet's Persona IQ smart knee implant is an innovative, FDA-approved medical device employed in total knee replacement surgery.
A SmarterWay to Regain Mobility1,2*This stem contains sensors that capture motion data allowing your surgeon and care team to monitor your knee's function after surgery. Your Persona IQ implant ...
Smart Knee ImplantThe information collected by Persona IQ allows your physician to remotely view your knee data throughout your recovery. Through the latest implant technology, ...
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