Cognitive-Motor Training for Mild Cognitive Impairment

SW
Overseen ByShuaijie Wang, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Illinois at Chicago
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a new program designed to help people with Mild Cognitive Impairment (MCI) improve balance, memory, and overall quality of life. The study compares CogXergaming, a novel cognitive-motor training program, with a standard exercise and education program. Participants will engage in 18 sessions over eight weeks, using computer technology to make the exercises more engaging and tailored to their needs. This trial suits those who can walk unaided, have MCI based on specific criteria, and are not taking sedative drugs. As an unphased trial, it offers a unique opportunity to contribute to innovative research that could enhance the quality of life for those with MCI.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are on sedative drugs. If you have uncontrolled hypertension, you must be on medication to manage it.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research shows that computer-based brain training, such as the Novel CogXergaming Training, is safe for older adults with mild memory problems. Studies have found that similar programs are easy to manage, with few reports of negative effects. One study specifically mentioned that the CogXergaming method is safe for older adults. Overall, evidence suggests that this type of training is generally safe and doesn't cause major side effects.12345

Why are researchers excited about this trial?

Researchers are excited about the Novel CogXergaming Training for mild cognitive impairment because it uniquely combines cognitive and motor exercises in an interactive gaming format. Unlike traditional treatments that often rely on medication or separate cognitive and physical exercises, this approach uses a desktop with a webcam to create a fun, engaging experience that targets both mind and body. This innovative method aims to enhance cognitive function and balance simultaneously, offering a potentially more holistic and enjoyable way to address mild cognitive impairment.

What evidence suggests that this trial's treatments could be effective for Mild Cognitive Impairment?

Research has shown that the Novel CogXergaming Training, which participants in one arm of this trial will receive, can help individuals with Mild Cognitive Impairment (MCI) enhance their balance and cognitive skills. One study found that using an exergame, a video game designed for exercise, improved both balance and mental abilities. Another study discovered that CogXergaming is suitable for older adults, helping them stay active and improve their quality of life. Early findings suggest that this game-based training is not only enjoyable but also effective in boosting both physical and mental skills. Overall, evidence indicates that this training could be a promising option for those seeking to enhance movement and cognitive abilities and reduce the risk of falls.36789

Who Is on the Research Team?

SW

Shuaijie Wang, PhD

Principal Investigator

University of Illinois at Chicago

Are You a Good Fit for This Trial?

This trial is for older adults with Mild Cognitive Impairment (MCI), which is an early stage of dementia. Participants should be experiencing issues with memory, gait, and balance but still able to engage in physical activity. Specific eligibility criteria are not provided.

Inclusion Criteria

Can understand and communicate in English
Identification of Mild Cognitive Impairment (MCI) based on Jak/Bondi criteria
I am between 55 and 90 years old.
See 4 more

Exclusion Criteria

Heart Rate >85% of age-predicted maximal heart rate (HRmax) at baseline measurement
Systolic blood pressure (SBP) > 160 mmHg and/or diastolic blood pressure (DBP) > 110 mmHg during resting at baseline measurement
Exhibits difficulty understanding the study information
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo 8 weeks of CogXergaming Training (CXT) or Exercise and Education Program (EEP), with 18 sessions total

8 weeks
18 sessions (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, including assessments of cognitive and physical function

8 weeks
2 visits (in-person)

Exploratory Analysis

Focus groups conducted to assess system usability, acceptability, and motivation

What Are the Treatments Tested in This Trial?

Interventions

  • Novel CogXergaming Training
Trial Overview The study tests a new CogXergaming training program designed to improve cognitive-motor function in older adults with MCI. It combines exercise with cognitive tasks using computer vision and cloud technology to enhance engagement and personalization.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: Novel CogXergaming TrainingExperimental Treatment1 Intervention
Group II: Exercise and Education Training ProgramExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Illinois at Chicago

Lead Sponsor

Trials
653
Recruited
1,574,000+

Citations

Effectiveness of an Individualized Exergame-Based Motor ...This study systematically explores the effectiveness of a newly developed exergame-based motor-cognitive training concept (called “Brain-IT”) targeted to ...
NCT07160582 | Cognitive-Motor Training for AD/ADRD PreventionAim 3: We will examine the immediate and sustained effects of CXT on patient-centered measures of physical activity, falls efficacy, and quality of life, and ...
Effects of Different Intensity Exergame Balance Training on ...The objective is to determine the relationship and effects of exergame balance training of different intensities on balance and cognition in ...
Gaming-Based Tele-Exercise Program to Improve Physical ...These pilot findings indicate that CogXergaming is feasible and applicable in prefrail older adults. Such game-based protocols can be beneficial ...
A Difficulty Based Comparison of Novel Exergame Balance ...A Difficulty Based Comparison of Novel Exergame Balance Training for Cognitive Functions in Adults with Mild Cognitive Impairment: A Randomized Trial. September ...
a systematic review and meta-analysis - PMC - PubMed CentralThis is a comprehensive systematic review and meta-analysis evaluating the effects of computerised cognitive training in older adults with mild ...
(PDF) Evaluating the Clinical Effectiveness of an Exergame ...Mild cognitive impairment (MCI), mild neurocognitive disorder (mNCD), and mild-to-moderate dementia Seven studies investigated the effects of exergame-based ...
Effectiveness of a Novel Exergame-Based Training ...OBJECTIVES: This study systematically explores the effectiveness of a newly developed exergame-based motor-cognitive training concept (called ' ...
The Efficacy of Cognitive Training on Neuropsychological ...Results showed that CT significantly improved global cognitive functioning, short-term and long-term verbal memory, generativity, working memory ...
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