Respiratory Self-Rescue Intervention for Anesthesia

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Utah
Must be taking: Opioid analgesics
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new method to improve patients' breathing after surgery. Standard medical monitors detect when a patient isn't breathing well and play a nurse's voice that calls the patient by name to remind them to breathe. The trial focuses on patients who stay in the hospital for at least 24 hours after surgery and may have sleep apnea or require strong pain medication like opioids. Participants in one group will hear the voice prompts, while the control group will not. The trial aims to determine if the voice prompts, part of the NM3 intervention, can enhance breathing without relying solely on traditional alarms.

As an unphased trial, this study provides patients an opportunity to contribute to innovative research that could improve post-surgery care.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to consult with the study coordinators or your doctor for guidance.

What prior data suggests that this intervention is safe for patients?

Research has shown that the NM3 monitoring system used in this study is generally safe. It has been applied in various medical settings, including with newborns, without major safety issues. The device includes common monitors, such as a pulse oximeter, which checks blood oxygen levels and is widely used and well-tolerated.

No reports have linked problems directly to the NM3 system in the available studies. This suggests that the monitoring tools and methods, including the voice prompts used in this trial, are likely safe for participants. However, as the trial is still in its early stages, researchers will continue to monitor safety and effectiveness.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores a novel method for improving patient safety during anesthesia. Unlike traditional approaches that rely on monitoring equipment and medical staff intervention, this technique uses recorded verbal prompts and physical cues, like a shoulder shake, to encourage patients to breathe on their own. This innovative approach could enhance patient autonomy and potentially reduce the need for additional medical interventions during anesthesia, offering a fresh perspective on managing respiratory challenges in surgical settings.

What evidence suggests that this intervention is effective for detecting ventilatory depression during anesthesia?

Research has shown that audio prompts reminding patients to breathe can help prevent breathing problems during anesthesia. In this trial, the experimental group will hear recorded verbal prompts to breathe, with an optional shoulder shake, to maintain better breathing patterns and reduce the risk of breathing issues. Standard monitors, similar to those used for sleep apnea, detect when a patient might not be breathing well. Then, a recorded voice gently reminds them to take a breath. This simple reminder aims to make anesthesia safer by encouraging regular breathing without more invasive methods. Meanwhile, the control group will not receive prompts from the recorded voice.678910

Who Is on the Research Team?

KB

Ken B Johnson, MD

Principal Investigator

University of Utah

Are You a Good Fit for This Trial?

This trial is for patients who will stay in the hospital at least 24 hours after surgery, including those with known or high-risk obstructive sleep apnea (OSA), and nurses caring for these patients. It's not for day-surgery patients, pregnant women, prisoners, or those unable to consent.

Inclusion Criteria

PACU nurses who are in charge of caring for consented patients
I had surgery that required me to stay in the hospital for at least one day.
I have or might have sleep apnea based on a test or high STOP-Bang score.
See 1 more

Exclusion Criteria

Vulnerable populations including pregnant women, prisoners, and people requiring legally authorized representative for consent
I went home the same day as my surgery.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants are monitored for ventilatory depression and receive recorded verbal prompts to breathe during the first 24 hours post-surgery

24 hours
Continuous monitoring in PACU and hospital floor

Follow-up

Participants are monitored for safety and effectiveness after the initial 24-hour monitoring period

1 week

What Are the Treatments Tested in This Trial?

Interventions

  • NM3
Trial Overview The study tests if a nurse's recorded voice prompt from a device can encourage post-surgical patients to breathe when they show signs of breathing trouble. This works alongside traditional monitor alarms and uses standard patient monitors.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: ExperimentalExperimental Treatment1 Intervention
Group II: ControlActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Utah

Lead Sponsor

Trials
1,169
Recruited
1,623,000+

Published Research Related to This Trial

A review of 7827 safety reports from 2015 to 2020 revealed that only 67 (0.85%) were related to perioperative airway management, indicating that while these incidents are relatively rare, they can still pose significant risks to patients.
The most common adverse event was 'Intubation Injury,' accounting for 35.8% of airway management incidents, with the majority of events causing temporary or minor harm, highlighting the need for improved training and resources to enhance patient safety.
Airway management in the operating room setting: An analysis of reported safety events.Osgood, KB., Krishnan, S., Wheeler, KK., et al.[2022]
From 2010 to 2015, a review of 2544 adverse events in pediatric anesthesia revealed that the most common issues were cardiac arrests (31.6%), respiratory complications (29.2%), and medication errors (16.9%).
A striking 85% of anesthesia-related serious adverse events were considered preventable, highlighting the need for innovations focused on reducing medication errors to enhance patient safety.
Outcomes from wake up safe, the pediatric anesthesia quality improvement initiative.Haché, M., Sun, LS., Gadi, G., et al.[2021]

Citations

Outcomes in patients who received ECMO and/or volatile ...Outcomes in patients who received ECMO and/or volatile anesthetics as rescue therapies for status asthmaticus - PMC.
Outcomes and measures in studies of techniques to promote ...The most common resource-use outcome was hospitalisation due to respiratory illness (n=13, 17%). Few studies reported on life impact outcomes, with the most ...
Baseline respiratory system compliance and its decline ...We studied the association of low Crs at the induction of anesthesia (iCrs) with limited intraoperative respiratory management.
Abstracts of the ICARE 2022 76th SIAARTI National CongressWe performed a prospective analysis of 13 patients undergoing general anesthesia (8 elective surgery, 5 urgent surgery), with continuous ...
Utilization Patterns And Patient Outcomes Associated With ...To investigate the practice patterns and clinical outcomes associated with use of rescue therapies in patients with acute lung injury.
Respiratory Depression in Non-Operating Room AnesthesiaAnalysis of the Anesthesia Closed Claims database suggests that adverse respiratory events continue to be the main cause of morbidity and ...
Nonoperating room anaesthesia: safety, monitoring, cognitive ...This review looks at implications for the practitioner and patient safety, outlining considerations and steps involved in translation of systems and processes
Respiratory Function Monitors (RFMs) Used for Newborn ...Philips NM3 respiratory data were collected using the NICO Data Collection (SW:V1.5.2) and Flow Tool software (SW:V2.21.0)(Philips ...
Effect of increased resistance on dynamic compliance ...The study group exhibited a significant increase in respiratory system compliance (P < 0.05) and improved intraoperative oxygenation (P < 0.05).
Safety and effectiveness of inhaled sedation in critically ill ...The use of inhaled sedation may be safe and effective for critically ill patients. Data availability. All data generated or analysed during this ...
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