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Sedentary RE for Physical Activity (MoTrPAC Trial)

N/A
Recruiting
Led By Mike Miller, PhD
Research Sponsored by University of Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Aged ≥18 years
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline; week 12
Awards & highlights

MoTrPAC Trial Summary

This trial is looking at how physical activity affects the body at a molecular level.

Who is the study for?
Adults aged 18+ who can read and speak English, are willing to consent, and have a BMI between 19-35 kg/m2. Participants should be either sedentary (exercising no more than once a week) or highly active in endurance or resistance training for over a year. Those with certain chronic diseases, recent drug use that affects exercise response, or planning significant weight changes are excluded.Check my eligibility
What is being tested?
The MoTrPAC study is testing how the body's molecules respond to different types of physical activity. Adults will do endurance training (like running), resistance training (like lifting weights), or no exercise at all for about 12 weeks while scientists observe molecular changes.See study design
What are the potential side effects?
Since this trial involves common forms of physical activity rather than medication, side effects may include typical exercise-related issues such as muscle soreness, fatigue, and risk of injury if exercises are performed improperly.

MoTrPAC Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.

MoTrPAC Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline; week 12
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline; week 12 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cardiopulmonary Exercise Test (CPET) VO2 Peak
Isometric Knee Peak Torque by Group
Secondary outcome measures
HDL-C
HbA1C
LDL-C
+1 more

MoTrPAC Trial Design

5Treatment groups
Active Control
Group I: Highly Active EEActive Control1 Intervention
A comparison group of highly active EE participants are recruited and engage only in the initial round of acute exercise testing. Highly Active Endurance Exerciser (HAEE) participants are tested on a cycle ergometer.
Group II: Sedentary REActive Control1 Intervention
Participants randomized to RE first engage in a single acute exercise test of Resistance Exerciser, consistent with their random assignment.
Group III: Highly Active REActive Control1 Intervention
A comparison group of highly active RE participants are recruited and engage only in the initial round of acute exercise testing. Highly Active Resistance Exerciser (HARE) participants are tested via a bout of resistance exercise.
Group IV: Sedentary controlActive Control1 Intervention
The control group does not engage in any acute exercise testing protocol, but biospecimens are collected prior to and following a period of rest.
Group V: Sedentary EEActive Control1 Intervention
Participants randomized to EE first engage in a single acute exercise test of Endurance Exerciser (on a cycle ergometer) consistent with their random assignment.

Find a Location

Who is running the clinical trial?

University of FloridaLead Sponsor
1,338 Previous Clinical Trials
713,036 Total Patients Enrolled
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NIH
483 Previous Clinical Trials
1,084,659 Total Patients Enrolled
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,346 Previous Clinical Trials
4,312,128 Total Patients Enrolled

Media Library

Endurance Training Clinical Trial Eligibility Overview. Trial Name: NCT03960827 — N/A
Physical Activity Research Study Groups: Highly Active EE, Sedentary RE, Highly Active RE, Sedentary control, Sedentary EE
Physical Activity Clinical Trial 2023: Endurance Training Highlights & Side Effects. Trial Name: NCT03960827 — N/A
Endurance Training 2023 Treatment Timeline for Medical Study. Trial Name: NCT03960827 — N/A
Physical Activity Patient Testimony for trial: Trial Name: NCT03960827 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what extent can the participant numbers for this experiment reach?

"To fulfil the requirements of this clinical trial, 2,280 volunteers who meet its criteria must be recruited. These individuals can participate in East Carolina University (Greenville, NC) and Ball State University (Muncie IN)."

Answered by AI

What aims has this research endeavor set out to realize?

"During this trial period, which will encompass the Baseline and Week 12 points in time, our primary objective is to investigate Metabolome within muscle tissue. Additionally, we are looking into changes of Transcriptome levels in blood plasma, Proteome variations among plasma proteins, as well as any alterations regarding Metabolite concentrations found in said liquid sample."

Answered by AI

How many clinical centers are participating in this trial?

"Presently, nine different medical sites are hosting this trial; for example, Greenville, Muncie and San Antonio. To minimize travel requirements it may be beneficial to choose the nearest option if you decide to sign up."

Answered by AI

Are new participants being enrolled in this clinical investigation currently?

"As per clinicaltrials.gov, this medical trial is currently seeking participants. It was initially posted on August 28th 2019 and recently updated on October 11 2021."

Answered by AI

Who else is applying?

What state do they live in?
Alabama
Florida
Texas
How old are they?
18 - 65
What site did they apply to?
University of Alabama at Birmingham
Florida Hospital / Advent Health
Other
University of Texas Health Science Center, San Antonio
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
1
3+

Why did patients apply to this trial?

am trying to see why i have become so fateiged. With all of us in this world that want to have a better quality of life always searching for the best exercises, diets, etc to reach our goals, I decided after trying to find someone to help in the best way possible for myself this may be the answer and it may become a great help to not only myself but others. [:o}.
PatientReceived 1 prior treatment

What questions have other patients asked about this trial?

How long is each process in this trial~? How much does it cost~?
PatientReceived no prior treatments
~257 spots leftby Nov 2024