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Procedure

Radiofrequency Ablation for Thyroid Nodules

N/A
Recruiting
Led By Kim O Learned
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Benign nodule is >= 2 cm in the largest dimension, and has either solid, or predominantly solid composition (>= 70% volume) without large calcification. Nodule is confirmed as benign (Bethesda II) on at least 2 ultrasound guided fine needle aspirations (FNA) or core needle biopsy (CNB) or a single benign diagnosis of FNA or CNB when the nodule has benign ultrasound features (American College of Radiology [ACR] Thyroid Imaging Reporting & Data System [TI-RAD] TR 1-3, American Thyroid Association [ATA] very low suspicion) within 6 months of planned RFA
Presence of compression symptoms or cosmetic concerns for which patient request treatment of the benign thyroid nodule
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline up to 12 months
Awards & highlights

Study Summary

This trial studies radiofrequency ablation to treat patients with benign or low-risk thyroid nodules. The goal is to learn if it is as effective as surgery and if it has a better recovery response.

Who is the study for?
This trial is for adults over 18 with benign thyroid nodules or low-risk thyroid cancer who have symptoms, want treatment but can't or won't have surgery. They must be fit for local anesthesia, able to consent, and the nodule must be visible on ultrasound and confirmed benign or low-risk cancer without metastasis.Check my eligibility
What is being tested?
The study tests radiofrequency ablation (RFA), a less invasive procedure using electric current to heat and destroy tumor cells. It's compared to standard surgery in terms of effectiveness and recovery for treating thyroid nodules or small recurrent cancers.See study design
What are the potential side effects?
Potential side effects of RFA may include pain at the site of treatment, swelling, bruising, infection risk at the needle insertion point, temporary voice changes due to nerve irritation near the thyroid gland.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My benign nodule is at least 2 cm, mostly solid, and confirmed benign by tests.
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I want treatment for my thyroid nodule due to discomfort or appearance concerns.
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My thyroid nodule is suspicious but not clearly cancerous, or I have a small, local thyroid cancer without spread.
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My nodule can be reached through a specific surgical approach.
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I understand and agree to participate in the study.
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I am over 18 and cannot or will not have surgery.
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I am healthy enough for local anesthesia with or without sedation.
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I have a single thyroid nodule or a dominant one in a multinodular goiter.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline up to 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in thyroid nodule size
Secondary outcome measures
Cost of ultrasound-guided radiofrequency ablation (RFA)
Sonographic features of nodules
Treatment response that affect quality of life

Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment (RFA)Experimental Treatment2 Interventions
Patients undergo ultrasound guided RFA over 1-2 hours.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Radiofrequency Ablation
2013
Completed Phase 4
~740

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor
2,967 Previous Clinical Trials
1,804,702 Total Patients Enrolled
Kim O LearnedPrincipal InvestigatorM.D. Anderson Cancer Center

Media Library

Radiofrequency Ablation (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT05003856 — N/A
Thyroid Nodule Research Study Groups: Treatment (RFA)
Thyroid Nodule Clinical Trial 2023: Radiofrequency Ablation Highlights & Side Effects. Trial Name: NCT05003856 — N/A
Radiofrequency Ablation (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05003856 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are enrolled in this experiment?

"Affirmative. Clinicaltrials.gov attests that this research endeavour, which was initiated on August 29th 2022 and revised September 3rd 2022, is actively recruiting participants. The trial requires 100 people to be sourced from 1 medical centre."

Answered by AI

Does this research currently offer opportunities to participate?

"According to the details posted on clinicaltrials.gov, this medical trial is currently seeking out potential participants. It was initially uploaded on August 29th 2022 and its contents were last revised September 3rd 202"

Answered by AI

Who else is applying?

What state do they live in?
South Dakota
Alaska
How old are they?
18 - 65
65+
What site did they apply to?
M D Anderson Cancer Center
What portion of applicants met pre-screening criteria?
Met criteria

Why did patients apply to this trial?

My belief is that Ablation is my treatment of choice.
PatientReceived no prior treatments
~41 spots leftby Jun 2025