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Beta-Blocker

Propranolol for Cardiovascular Disease

Phase 4

Waitlist Available

Led By Keely Muscatell, PhD

Research Sponsored by University of North Carolina, Chapel Hill

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Ages 18-30 years

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up post-drug baseline to 90-minutes post-stress task (t-90)

Awards & highlights

Study Summary

This trial aims to understand how stress affects inflammation in the body, potentially leading to heart disease. This information may help in developing new treatments to lower the risk of cardiovascular problems.

Who is the study for?

This trial is for right-handed, English-fluent individuals aged 18-30 with a BMI of 35 or less. It's not for those with certain physical illnesses like heart conditions, high blood pressure, diabetes, autoimmune diseases; metal implants; current prescription medication users; pregnant women; severe claustrophobics; or regular nicotine/drug users.Check my eligibility

What is being tested?

The study investigates how the beta-blocker Propranolol affects stress-related inflammation and neural responses that could influence cardiovascular disease risk. Participants will be randomly given either Propranolol or a placebo to compare effects.See study design

What are the potential side effects?

Propranolol can cause side effects such as slower heart rate, fatigue, dizziness, and gastrointestinal discomfort. The severity of these side effects varies from person to person.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 30 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ post-drug baseline to 90-minutes post-stress task (t-90)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~post-drug baseline to 90-minutes post-stress task (t-90)

This trial's timeline: 3 weeks for screening, Varies for treatment, and post-drug baseline to 90-minutes post-stress task (t-90) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in levels of inflammatory gene expression in response to social stress

Change in levels of pro-inflammatory cytokine interleukin-6 in response to social stress

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: PropranololExperimental Treatment1 Intervention

Propranolol tablet, 40mg, one-time, orally

Group II: PlaceboPlacebo Group1 Intervention

Encapsulated placebo tablet

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Propranolol

2010

Completed Phase 4

~1290

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, Los AngelesOTHER

1,533 Previous Clinical Trials

10,265,448 Total Patients Enrolled

Dartmouth CollegeOTHER

81 Previous Clinical Trials

1,416,120 Total Patients Enrolled

University of North Carolina, Chapel HillLead Sponsor

1,508 Previous Clinical Trials

4,190,705 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the eligibility criteria for individuals seeking to enroll in this medical study?

"Individuals aged between 18 and 30 with a diagnosis of cardiovascular disease are eligible to enroll in this clinical research initiative, which is open for approximately 120 participants."

Answered by AI

Does this medical study seek to enroll individuals who are above the age of 50?

"Individuals aged between 18 and 30 are sought after for this research endeavor. It is noteworthy that there are numerous studies available, including 28 trials tailored to minors and 405 investigations focusing on individuals over the age of retirement."

Answered by AI

Are potential participants currently able to apply for enrollment in this study?

"Information available on clinicaltrials.gov states that the ongoing medical trial is presently not accepting new participants. Initially shared on February 1st, 2024 and most recently modified on February 8th, 2024, this study currently has no vacancies for enrolment. Nonetheless, there are a total of 455 alternative studies actively seeking suitable candidates at present."

Answered by AI