Anakinra for Inflammation

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Inflammation+1 MoreAnakinra - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether the drug Anakinra can help improve the exercise capacity of patients with heart failure and inflammation.

Eligible Conditions
  • Heart Failure
  • Inflammation
  • Systolic Heart Failure

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 8 Secondary · Reporting Duration: baseline - 24 weeks

baseline - 24 weeks
Biomarker - N-terminal pro b-type Natriuretic Peptide (NT-proBNP)
Biomarker - high sensitivity C-reactive protein (CRP)
Clinical Outcome - cardiac death
Clinical Outcome - hospitalization for heart failure
Quality of Life Assessments
changes in peak oxygen consumption (VO2)
echocardiography assessments
hemodynamic assessments
Week 12
changes in peak VO2 at earlier endpoints

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

anakinra
1 of 2
placebo
1 of 2

Experimental Treatment

Non-Treatment Group

102 Total Participants · 2 Treatment Groups

Primary Treatment: Anakinra · Has Placebo Group · Phase 2

anakinra
Drug
Experimental Group · 1 Intervention: Anakinra · Intervention Types: Drug
placebo
Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Anakinra
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline - 24 weeks

Who is running the clinical trial?

Virginia Commonwealth UniversityLead Sponsor
625 Previous Clinical Trials
365,670 Total Patients Enrolled
4 Trials studying Inflammation
46 Patients Enrolled for Inflammation
Antonio Abbate, MD, PhDPrincipal InvestigatorVirginia Commonwealth University
13 Previous Clinical Trials
408 Total Patients Enrolled
3 Trials studying Inflammation
27 Patients Enrolled for Inflammation

Eligibility Criteria

Age 18+ · All Participants · 10 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a stable hemodynamic parameters.