Lymphatic Reconstruction to Prevent Lymphedema After Skin Cancer Surgery
(LYMbR Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing a surgical technique called prophylactic LVA to prevent swelling in patients having lymph nodes removed due to skin cancer. The procedure creates new drainage paths for lymph fluid to reduce the risk of lymphedema. The study aims to see if this technique improves patients' quality of life and reduces complications.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
Is lymphaticovenous anastomosis (LVA) safe for preventing lymphedema after surgery?
How does the treatment Prophylactic Lymphaticovenous Anastomosis differ from other treatments for preventing lymphedema after skin cancer surgery?
Prophylactic Lymphaticovenous Anastomosis (LVA) is unique because it involves microsurgical techniques to connect lymphatic vessels to nearby veins immediately after lymph node removal, aiming to prevent lymphedema (swelling due to lymph fluid buildup) from developing. This approach is different from other treatments that typically address lymphedema after it has already occurred, rather than preventing it from the outset.25678
What data supports the effectiveness of the treatment Prophylactic Lymphaticovenous Anastomosis in preventing lymphedema after skin cancer surgery?
Research shows that prophylactic lymphaticovenous anastomosis (LVA) can reduce the risk of lymphedema (swelling due to fluid buildup) after cancer-related surgeries. A systematic review found that LVA significantly decreased the incidence of lymphedema in both upper and lower limbs after lymph node removal, suggesting it may be effective in preventing lymphedema after skin cancer surgery as well.25689
Who Is on the Research Team?
Claire Temple-Oberle, MD, MSc, FRCSC, MMEd
Principal Investigator
University of Calgary
Are You a Good Fit for This Trial?
Adults over 18 who are undergoing lymph node removal in the armpit or groin area due to skin cancer can join. It's not for those just getting a sentinel lymph node biopsy, with untreated limb disease, leg vein clots (post-thrombotic syndrome), pregnancy, prior radiation in the area, or pre-existing lymphedema.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Surgery and Prophylactic LVA
Participants undergo lymphadenectomy with or without prophylactic lymphaticovenous anastomosis
Follow-up
Participants are monitored for lymphedema development and quality of life at 6-month intervals
Long-term Follow-up
Participants undergo radionuclide lymphoscintigraphy to assess lymphatic function
What Are the Treatments Tested in This Trial?
Interventions
- Prophylactic Lymphaticovenous Anastomosis
Find a Clinic Near You
Who Is Running the Clinical Trial?
Alberta Health Services, Calgary
Lead Sponsor
University of Calgary
Collaborator
Tom Baker Cancer Centre
Collaborator