Treatment for Skin Pigment

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Utah John A. Moran Eye Center, Salt Lake City, UT
Skin Pigment+2 More
Eligibility
Any Age
All Sexes
Eligible conditions
Select

Study Summary

Macular Pigment Measurements in Eye & Other Tissues

See full description

Eligible Conditions

  • Skin Pigment
  • Macular Pigmentation

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 2 primary outcomes and 1 secondary outcome in patients with Skin Pigment. Measurement will happen over the course of at enrollment.

at enrollment
Carotenoid levels in the blood
Carotenoid levels in the eye
Carotenoid levels in the skin

Trial Safety

Trial Design

0 Treatment Group

This trial requires 10000 total participants across 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: at enrollment
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly at enrollment for reporting.

Who is running the study

Principal Investigator
P. S. B.
Prof. Paul S. Bernstein, Professor, Ophthalmology/Visual Sciences
University of Utah

Closest Location

University of Utah John A. Moran Eye Center - Salt Lake City, UT

Eligibility Criteria

This trial is for patients born any sex of any age. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Any patient age 7 or older, undergoing routine dilated ophthalmology examinations at the Moran Eye Center will be eligible to participate.
Patients with adult vitelliform dystrophy. (This condition initially presents in adulthood as bilateral subtle and often asymptomatic macular lesions, which are often misdiagnosed as early age-related macular degeneration (AMD)).

Patient Q&A Section

What is the average age someone gets ito syndrome?

"There are large variations in the age of onset for ITS. The mean age of onset of individuals with ITS is 39 years old, with an average age of onset at 32 years old for adult cases and an average age of onset at 10-20 years old for pediatric and adolescent cases." - Anonymous Online Contributor

Unverified Answer

Is treatment typically used in combination with any other treatments?

"The current study showed that approximately 80% of current and recently completed clinical trials are accompanied with some other treatments, and for some other treatments, there is no evidence of the combination." - Anonymous Online Contributor

Unverified Answer

How many people get ito syndrome a year in the United States?

"Approximately 10 to 15 percent who have been diagnosed, and 50 to 55 percent of those with clinically significant symptoms in the course of their illness, have the syndrome. Ito syndrome is associated with many other conditions and may only be diagnosed if a search for such conditions is conducted. Physicians caring for patients with ito syndrome should expect to learn about its association with many other conditions at every visit." - Anonymous Online Contributor

Unverified Answer

What are the signs of ito syndrome?

"Most patients complain of fatigue and low energy level. Neurological symptoms such as headache and visual field defects such as scotoma may also occur, which are suggestive of ito syndrome." - Anonymous Online Contributor

Unverified Answer

What causes ito syndrome?

"The precise cause for ito syndrome is unknown, but it is likely to be connected to physical, genetic, psychological and environmental variables. Drugs or traumatic events may also trigger ito syndrome." - Anonymous Online Contributor

Unverified Answer

What is ito syndrome?

"Ito's syndrome is a combination of congenital heart disease, pulmonary hypertension, and hypothermic shock. It is usually diagnosed by pulmonary hypertension and right ventricular dysfunction of young infants. Its symptoms may include cyanosis, tachycardia, hypotension, and pulmonary edema. Treatment for Ito's syndrome consists of supportive measures and mechanical circulatory support. The prognosis of Ito's syndrome is very poor. We reported a series of three cases of Ito's syndrome complicated by pulmonary thrombosis (1) and respiratory failure (2). All three patients were of Asian origin and neonates; (3) and 4) were in good health." - Anonymous Online Contributor

Unverified Answer

What are common treatments for ito syndrome?

"Ito syndrome patients are treated in a variety of ways depending on the symptoms in their disorder. Some patients may not be able to tolerate medication and may go on to try other alternatives like electroconvulsive therapy (ECT) or ketamine. Although many patients are prescribed antidepressants, some are intolerant to antidepressants due to adverse effects. Other treatments focus on the specific symptoms of the disease, and can include physical therapy and physical and occupational therapy." - Anonymous Online Contributor

Unverified Answer

Can ito syndrome be cured?

"The prognosis of ito syndrome was fairly good, while the average life expectancy of ito syndrome patients remained unchanged over the past several years. Due to its early onset, ito syndrome can only be managed by a multi-disciplinary team. While many patients develop severe complications like pulmonary and brain metastasis, it is important not to exclude any possibility of cure. Future research should focus on the exact cause of ito syndrome. With the recent development of novel treatment options, ito syndrome could become a curable disorder. © 2016 International Clinical Research Foundation. Published by the International Clinical Research Foundation Ltd." - Anonymous Online Contributor

Unverified Answer

What is treatment?

"Treatments can be grouped into four types: symptomatic therapy; symptomatic intervention; symptomatic intervention + treatment; or symptomatic intervention + treatment. Treatment is associated with decreased mortality and improvement of functional status." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of ito syndrome?

"It is known that ito syndrome is associated with the presence of an underlying autoimmune disorder. These autoimmune disorders are usually of the autoimmune gastrointestinal or dermatologic type and are not associated with diabetes or obesity. We emphasize an important clinical aspect in which we have taken care to clarify, that ito syndrome is not associated with insulin resistance. Results from a recent paper can be helpful in the evaluation of a possible association between ito syndrome and ito itself. Further, we highlight the presence of many other autoimmune disorders in ito, whose diagnosis and treatment can be difficult for the diagnostic pathologist. A diagnosis of many the coexisting disorders would aid the clinician in a thorough diagnostic workup and provide a better therapeutic strategy." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of treatment?

"Results from a recent clinical trial has shown that it is possible to identify the most common side effects and their incidence at different time points in treatment. The most common side effects occurred at the initial stage, whereas some side effects only became apparent after treatment had been halted. We recommend that the prescribing doctor check the list of side effects every ten days during the treatment." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for ito syndrome?

"The majority of patients with CLL should consider a clinical trial. The patient's sex, age, and stage of disease play an important role as well. Because clinical trials can be harmful and may lead to complications from chemotherapy or radiation therapy, the risks must be carefully weighed against potential benefits. Patients who opt for the trial should know that they will have high rates of treatment failure and remission, but the benefits of a longer life mean that they may be happier alive than they were dead." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Skin Pigment by sharing your contact details with the study coordinator.