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T-VEC + Pembrolizumab for Sarcoma
Study Summary
This trial is testing a new cancer treatment that uses two drugs.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- Criterion: You are sensitive to talimogene laherparepvec or pembrolizumab, or have a history of lung disease. You have received certain treatments or surgeries within 21 days before the study starts, are currently in another clinical trial, or have had psychiatric or substance abuse issues.My brain metastases are stable and haven't progressed in the last 4 weeks.Women who could become pregnant must have a negative pregnancy test before starting the study.My cancer is one of the specific types: undifferentiated pleomorphic sarcoma, myxofibrosarcoma, epithelioid sarcoma, or cutaneous angiosarcoma.I do not have a weakened immune system due to conditions like HIV, autoimmune diseases, or recent live vaccines.I have a tumor or node that can be injected, is at least 10mm big, and hasn't been previously treated with radiation unless it's grown.My organs are functioning well, as tested within the last 3 weeks.I have advanced sarcoma and have either tried a treatment, there's no standard treatment for my type, or I've refused standard treatment.I do not have any uncontrolled illnesses or infections needing treatment.I am 18 years old or older.My sarcoma cannot be removed by surgery and has spread.I am fully active or able to carry out light work.I have another active cancer besides the one being treated.
- Group 1: Talimogene Laherparepvec (T-VEC) Administered with Pembrolizu
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How has Talimogene Laherparepvec (T-VEC) been applied to medical treatment?
"Talimogene Laherparepvec (T-VEC) is a viable option for treating malignant neoplasms, microsatellite instability high, and unresectable melanoma."
Are there any vacancies present in this clinical experiment?
"According to clinicaltrials.gov, this medical investigation is currently recruiting patients. The trial was initially published on 3rd March 2017 and the most recent amendment occurred on 13th June 2022."
To what degree is Talimogene Laherparepvec (T-VEC) detrimental to patient health?
"As T-VEC is currently in Phase 2, our team at Power has assessed its safety to be a score of 2. This indicates that while there is some evidence suggesting the drug's security, no data exists yet regarding efficacy."
Is there any prior research pertaining to Talimogene Laherparepvec (T-VEC)?
"At present, there are 978 clinical trials associated with Talimogene Laherparepvec (T-VEC), 122 of which have advanced to Phase 3. Although the bulk of these studies take place in Houston, Texas, a total of 35828 locations worldwide are hosting investigations for T-VEC treatments."
How many participants are being accepted to this medical research initiative?
"Affirmative. Clinicaltrials.gov data reveals that this medical experiment is currently recruiting participants, after being initially published on March 3rd 2017 and most recently updated on June 13th 2022. This endeavour requires 50 volunteers across 2 sites."
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