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Metformin for Cystic Fibrosis
Study Summary
This trial will test if metformin can help improve airway function in those with CF-related diabetes.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I do not have heart, kidney, nerve, mental health, hormone, or cancer conditions that could affect my study participation.Your liver enzymes or bilirubin levels are higher than they should be.I am over 18 and have been diagnosed with cystic fibrosis.I use supplemental oxygen.I have used steroids or anti-inflammatory drugs in the last 30 days.I have been taking ivacaftor or elexacaftor/tezacaftor/ivacaftor for the last 30 days.I was hospitalized or needed IV antibiotics for a lung flare-up in the last 30 days.I am taking medication that interacts with metformin.I have had a lung or liver transplant.You have low levels of vitamin B12 in your body.I am not taking any strong medication that affects liver enzymes.Your body mass index (BMI) is less than 18.I have diabetes due to cystic fibrosis and still have high blood sugar after 6 months of specific treatment.
- Group 1: Metformin dose regimen B
- Group 2: Metformin dose regimen A
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any other ongoing investigations involving Metformin Hydrochloride?
"At this time, there are a total of 180 clinical trials studying the effects of Metformin Hydrochloride. Of these investigations, 45 are in Phase 3. Although many studies for Metformin Hydrochloride originate from Pittsburgh, Pennsylvania, there are 1952 locations conducting research on this medication."
What type of medical conditions is Metformin Hydrochloride often used as a treatment for?
"Metformin Hydrochloride is frequently used to help people recover from strenuous exercise. However, it can also be taken as medication for type 1 diabetes mellitus, diabetic ketoacidosis, and polycystic ovary syndrome."
Are there any vacancies in this trial for potential participants?
"The trial you are inquiring about is recruiting patients, as denoted on clinicaltrials.gov. The posting went up on February 14th, 2022 and was edited more recently on March 1st, of the same year."
Is it dangerous to take Metformin Hydrochloride?
"Metformin Hydrochloride is in Phase 2 of clinical trials, meaning that while there is evidence supporting its safety, none exists yet for the medication's efficacy."
How many people are currently enrolled in this clinical trial?
"Yes, according to the most recent update on clinicaltrials.gov, this trial is looking for 36 participants at 1 site. The trial was first posted on February 14th, 2022 and was last updated on March 1st, 2022."
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