Surgery + Re-Irradiation for Recurrent Ependymoma
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if surgery combined with a second round of radiation (re-irradiation) can effectively treat ependymoma, a brain tumor that has returned after initial treatment. Researchers are assessing the effectiveness of this approach and potential side effects. They will analyze tumor and blood samples to understand the tumor's response to treatment and use advanced imaging techniques to predict treatment outcomes. Individuals whose brain tumor has recurred after radiation and who have not undergone whole-brain radiation may be suitable candidates for this trial. As a Phase 2 trial, the research focuses on evaluating the treatment's effectiveness in an initial, smaller group of participants.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that surgery and additional radiation can effectively treat recurrent ependymoma, a type of brain tumor. Studies have found that patients often live longer, especially when surgeons completely remove the tumor, a procedure known as gross total resection (GTR).
These treatments are generally safe and well-tolerated. One study found that patients with recurring ependymoma managed the treatments well and maintained good control over the tumor in the treated area. However, there remains a risk of the cancer spreading to other parts of the body.
While these treatments appear promising, it is important to note that the trial is in Phase 2. Researchers are still evaluating the safety and effectiveness of the treatments. Participants should be aware that higher doses of radiation are being used, which might cause more side effects. Discussing potential risks and benefits with a healthcare provider before joining a trial is always advisable.12345Why are researchers excited about this trial's treatments?
Researchers are excited about these treatments for recurrent ependymoma because they combine surgery with advanced re-irradiation techniques like photon and proton therapy. Unlike traditional treatments that might focus solely on either surgery or radiation, this approach uses both to target tumor cells more effectively. Additionally, the use of imaging agents like ^18F-fluorodeoxyglucose and ^11C-methionine helps visualize the tumor better, potentially leading to more precise treatment. This dual strategy aims to improve outcomes in cases of local or metastatic recurrence, offering hope for those with this challenging condition.
What evidence suggests that surgery and re-irradiation could be effective for recurrent ependymoma?
Research has shown that combining surgery with a second round of radiation therapy can help treat recurrent ependymoma. In this trial, participants will be assigned to different treatment arms based on their pattern of disease failure. Some will receive surgery and craniospinal irradiation, while others will receive surgery and a second course of focal irradiation. Studies have found that this approach can help patients live longer without the cancer worsening and can also increase overall survival rates. Specifically, one retrospective study found that a second round of targeted radiation given in small doses was effective when ependymoma returned, with fewer instances of the cancer spreading. These findings suggest that using both surgery and re-irradiation could be a promising option for those facing recurrent ependymoma.12367
Who Is on the Research Team?
Thomas Merchant
Principal Investigator
St. Jude Children's Research Hospital
Are You a Good Fit for This Trial?
This trial is for individuals aged 1-21 with recurrent ependymoma, a type of brain tumor, after initial radiation treatment. They must be at least 9 months post-initial therapy and able to perform daily activities without mechanical ventilation. Pregnant women, patients who had prior full-spine irradiation or are under 3 years old with metastatic ependymoma cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Surgery
Participants undergo surgery as part of the treatment for recurrent ependymoma
Radiation Therapy
Participants receive fractionated re-irradiation therapy, with evaluations done weekly
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Irradiation
- Surgery
Irradiation is already approved in European Union, United States, China for the following indications:
- Medulloblastoma
- Brain tumors
- Cancer treatment
- Medulloblastoma
- Brain tumors
- Cancer treatment
- Medulloblastoma
- Brain tumors
- Cancer treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
St. Jude Children's Research Hospital
Lead Sponsor