Ketogenic Diet for Schizophrenia
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether a ketogenic diet can improve cognitive issues, such as thinking and memory problems, in people with schizophrenia or bipolar disorder. The ketogenic diet, high in fats and low in carbohydrates, might stabilize brain energy use and enhance brain function. Participants will either follow this specific diet or continue their regular eating habits for four weeks. Individuals with schizophrenia or bipolar disorder who are stable on medication and willing to try a new diet or maintain their current one might be suitable for this study. As an unphased trial, this study offers a unique opportunity to contribute to understanding dietary impacts on mental health.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you must be stable on a 2nd generation anti-psychotic for schizophrenia or schizoaffective disorder. You cannot participate if you are taking glucose-lowering drugs (other than metformin) or weight loss pills.
What prior data suggests that the ketogenic diet is safe for people with schizophrenia and bipolar disorder?
Research has shown that ketogenic diets can be safe and well-tolerated for individuals with serious mental illnesses, such as schizophrenia. In some studies, participants with schizophrenia who followed a ketogenic diet experienced improvements in overall health, including the reversal of issues like metabolic syndrome, which involves high blood pressure and high blood sugar.
This diet is high in fats and low in carbohydrates, altering how the body obtains energy. Instead of using sugar, the body uses ketones, derived from fat. This shift can positively affect brain health.
However, like any dietary change, some individuals might experience side effects. These can include fatigue, headaches, or nausea, often referred to as the "keto flu." These symptoms are usually temporary as the body adjusts to the new diet.
Overall, the ketogenic diet has been studied for its potential benefits on brain health and is generally considered safe. It is important to consult a healthcare provider before making any dietary changes, especially for those with existing health conditions.12345Why are researchers excited about this trial?
The ketogenic diet is unique for treating schizophrenia because it shifts the body’s metabolism by emphasizing high-fat and low-carbohydrate intake, leading to the production of ketone bodies. Unlike traditional treatments like antipsychotic medications that target neurotransmitters, this diet induces a fasting-like state that may affect brain energy metabolism differently. Researchers are excited because this approach offers a non-pharmaceutical option that could potentially reduce symptoms without the side effects often associated with standard medications.
What evidence suggests that a ketogenic diet might be an effective treatment for schizophrenia?
Research suggests that the ketogenic diet, which participants in this trial may receive, might help individuals with schizophrenia and bipolar disorder. This diet is high in fats and low in carbohydrates. Studies have shown it can improve symptoms in those with serious mental health issues. For instance, a small study found that the ketogenic diet not only improved mental health but also reduced insulin resistance, a condition where the body doesn't use insulin properly. The diet may also boost brain energy by providing ketones, which can offer more energy than sugar. While more research is needed, early findings are promising for using the ketogenic diet to address thinking and memory problems in these conditions.12367
Are You a Good Fit for This Trial?
This trial is for adults aged 18-65 with schizophrenia or schizoaffective disorder stable on second-generation antipsychotics, or bipolar disorder. Participants must speak English, have internet access, and be able to heat up ketogenic meals. They should commit to a 4-week ketogenic diet. Exclusions include current cancer diagnosis, other major psychiatric disorders, pregnancy/breastfeeding, type 1 diabetes, history of weight loss surgery or significant weight changes.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to either a ketogenic diet or diet as usual for 4 weeks to assess changes in neural network instability, metabolic, and inflammatory indices.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including changes in network stability, body composition, systemic inflammation, and insulin resistance.
What Are the Treatments Tested in This Trial?
Interventions
- Ketogenic diet
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northern California Institute of Research and Education
Lead Sponsor