NAD+ Augmentation for Acute Kidney Injury
(NACAM Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the drug Niacinamide for treating acute kidney injury?
Research suggests that boosting NAD+ levels, which Niacinamide is a part of, may help repair DNA damage and reduce inflammation in kidney cells, potentially improving outcomes after acute kidney injury. Additionally, Niacin, another form of vitamin B3 like Niacinamide, has shown protective effects on heart and kidney function in animal studies.12345
Is NAD+ augmentation safe for humans?
Nicotinamide (a form of vitamin B3) and its related compounds, which help increase NAD+ levels, have been studied in various conditions and are generally considered safe in humans. However, specific safety data for acute kidney injury is limited, and more research is needed to confirm its safety in this context.13456
How does the drug Niacinamide differ from other treatments for acute kidney injury?
What is the purpose of this trial?
A Randomized, Double-blind, placebo-controlled Trial to Evaluate the Efficacy of Oral Nam for the Prevention of Acute Kidney Injury in Patients Undergoing On-Pump Cardiac Surgery
Eligibility Criteria
This trial is for adults over 18 who need non-emergency heart surgery with a pump and are at high risk of heart-related complications. Eligible participants include those with valve surgeries, weak kidney function, reduced heart pumping capacity, history of heart failure or diabetes, protein in urine, anemia, previous bypass surgery or age 65+.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either Nam 3 grams or placebo on the day of surgery and post-surgical days one and two
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Niacinamide
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
Kaiser Permanente
Lead Sponsor
Beth Israel Deaconess Medical Center
Collaborator
Cedars-Sinai Medical Center
Collaborator
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator