Sulindac for Breast Cancer

Phase-Based Progress Estimates
Cedars Sinai - Cancer, Los Angeles, CABreast CancerSulindac Pill - Drug
35 - 70
What conditions do you have?

Study Summary

This trial will test whether sulindac can help reduce breast density in postmenopausal women who are at increased risk of breast cancer.

Eligible Conditions
  • Breast Cancer

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 2 Secondary · Reporting Duration: 12 months

12 months
Change in percent breast density by MRI
6 months
Change in collagen fiber alignment by second harmonic generation microscopy in breast tissue by biopsy
Changes in collagen type in breast tissue by whole slide mass spectrometry of tissue biopsy

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

1 of 2
1 of 2

Active Control

Non-Treatment Group

150 Total Participants · 2 Treatment Groups

Primary Treatment: Sulindac · Has Placebo Group · Phase 2

PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug
ActiveComparator Group · 1 Intervention: Sulindac Pill · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 12 months

Who is running the clinical trial?

Stony Brook UniversityLead Sponsor
201 Previous Clinical Trials
35,444 Total Patients Enrolled
5 Trials studying Breast Cancer
150 Patients Enrolled for Breast Cancer
Medical University of South CarolinaOTHER
850 Previous Clinical Trials
5,389,786 Total Patients Enrolled
8 Trials studying Breast Cancer
22,907 Patients Enrolled for Breast Cancer
Cedars-Sinai Medical CenterOTHER
462 Previous Clinical Trials
151,233 Total Patients Enrolled
14 Trials studying Breast Cancer
706 Patients Enrolled for Breast Cancer
Alison S Stopeck, MDPrincipal InvestigatorStony Brook University
Patricia A Thompson-Carino, PhDPrincipal InvestigatorStony Brook University

Eligibility Criteria

Age 35 - 70 · Female Participants · 8 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:

Frequently Asked Questions

Is this trial the inaugural attempt at a study of its kind?

"Currently, 4 experiments surrounding Sulindac are being conducted across 623 cities in 2 different countries. In 2013, Cancer Prevention Pharmaceuticals, Inc. commenced a Phase 3 trial with 1340 participants; since then 18334 additional trials have been finalized." - Anonymous Online Contributor

Unverified Answer

Could you elucidate the potential risks of taking Sulindac?

"Taking into consideration the Phase 2 nature of this trial, our team at Power estimated Sulindac's safety to be a score of 2 due to limited data on its efficacy." - Anonymous Online Contributor

Unverified Answer

What is the maximum number of participants for this experiment?

"Affirmative. According to, this medical trial continues its search for 150 participants at two different locations since it was first posted on November 20th 2020 and edited more recently on February 23rd 2022." - Anonymous Online Contributor

Unverified Answer

In what conditions is Sulindac typically prescribed?

"Generally, sulindac is utilized to manage acute subacromial bursitis. Additionally, the drug has been demonstrated to be effective for cases of [osteoarthritis]( (OA), acute supraspinatus tendinitis, and gouty arthritis." - Anonymous Online Contributor

Unverified Answer

Is enrollment for this research project still open?

"According to, this research project continues to search for additional participants since its first posting on November 20th 2020 and most recent update on February 23rd 2022." - Anonymous Online Contributor

Unverified Answer

Could you elucidate the past investigations that have utilized Sulindac?

"In 2013, Lake Norman Hematology Oncology Specialists-Mooresville first began examining sulindac. Nowadays, there are 18334 completed trials and 4 studies in the process of recruitment; many of these involve Stony Brook University's New York campus." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.