330 Participants Needed

LY3372689 for Alzheimer's Disease

Recruiting at 99 trial locations
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Overseen ByThere may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-CTLILLY (1-877-285-4559) or
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: Eli Lilly and Company
Prior Safety DataThis treatment has passed at least one previous human trial

Trial Summary

What is the purpose of this trial?

This trial is testing a new drug, LY3372689, on people with early symptoms of Alzheimer's Disease to see if it is safe and how it affects their symptoms.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research Team

C1

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

Principal Investigator

Eli Lilly and Company

Eligibility Criteria

This trial is for people with early symptomatic Alzheimer's Disease, who have experienced a gradual memory decline for at least 6 months. Participants should score between 22 to 30 on the MMSE (a cognitive test) and meet specific criteria on a PET brain scan. They need a study partner willing to consent as well.

Inclusion Criteria

Meet 18F flortaucipir positron emission tomography (PET) scan (central analysis) criteria
MMSE score of 22 to 30 (inclusive) at baseline
Have a study partner who will provide written informed consent to participate
See 2 more

Exclusion Criteria

Have known allergies to LY3372689, related compounds, or any components of the formulations
Contraindication to MRI or PET scans

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive LY3372689 or placebo orally to assess safety, tolerability, and efficacy

76 to 124 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • LY3372689
  • Placebo
Trial OverviewThe trial is testing LY3372689, which is being investigated for safety and effectiveness in treating Alzheimer's. Participants will either receive LY3372689 or a placebo without knowing which one they are getting to compare results fairly.
Participant Groups
3Treatment groups
Experimental Treatment
Placebo Group
Group I: LY3372689 Low DoseExperimental Treatment1 Intervention
LY3372689 given orally
Group II: LY3372689 High DoseExperimental Treatment1 Intervention
LY3372689 given orally
Group III: PlaceboPlacebo Group1 Intervention
Placebo given orally

Find a Clinic Near You

Who Is Running the Clinical Trial?

Eli Lilly and Company

Lead Sponsor

Trials
2,708
Recruited
3,720,000+
Dr. Daniel Skovronsky profile image

Dr. Daniel Skovronsky

Eli Lilly and Company

Chief Medical Officer since 2018

MD from Harvard Medical School

David A. Ricks profile image

David A. Ricks

Eli Lilly and Company

Chief Executive Officer since 2017

BSc from Purdue University, MBA from Indiana University