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Chemotherapy + Radiation + Bevacizumab for Lung Cancer
Study Summary
This trial is testing a combination of chemotherapy drugs, radiation therapy, and the drug bevacizumab in treating patients with newly diagnosed stage III non-small cell lung cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check βYesβ for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I do not have any serious, nonhealing wounds or broken bones.I do not have a serious heart rhythm problem that needs medication.You need to have a negative pregnancy test.I have no cancer history except for certain skin cancers, early-stage cancers in remission, or any cancer I've been free from for 5 years.I have not had chemotherapy or radiotherapy for lung cancer.I do not have serious blood vessel problems in my arms or legs.It's been over 4 weeks since my last major surgery and I have recovered.Your disease can be seen on a CT scan or MRI.My condition cannot be treated with surgery.My lung cancer is confirmed to be non-small cell type.I have no cancer history except for certain skin cancers, early-stage cancers in remission, or any cancer I've been free from for 5 years.I haven't had a heart attack or unstable chest pain in the last 6 months.It has been over a week since my last biopsy or mediastinoscopy.I have not had surgery to remove my condition.I've had surgery to diagnose or stage my lung cancer.I have not had a stroke in the last 6 months.My cancer has not spread to the opposite chest, liver, or adrenals.I have a small amount of fluid in my chest, only seen on scans.My lung cancer is non-squamous and considered low risk.My lung cancer is considered high-risk based on its type and test results.I will use birth control during and for 6 months after my last bevacizumab dose.My cancer is at stage IIIB with specific conditions.I am not currently undergoing intensity-modulated radiotherapy.I have 1 or fewer lung lesions.You do not have cancer that has spread to your brain.I do not have any serious wounds, ulcers, or broken bones that are not healing.My condition was recently diagnosed.I have not had cancer before, except for certain types.I am not currently receiving any other cancer treatments.I have not had surgery to remove my condition.I am not currently receiving any specialized radiation treatments.I am not receiving preventive radiation therapy to lymph nodes near my collarbone or opposite lung.My lung can handle the planned radiation dose without too much damage.I am not receiving any other cancer treatments right now.I am not currently receiving any specialized radiation treatments.You do not have fluid around your heart.I have not had chemotherapy or radiotherapy for lung cancer.My cancer stage fits one of the trial's required stages.It's been over 4 weeks since my last major surgery and I have recovered.I am not on any full-dose blood thinners.You do not have any bleeding or blood clotting problems.If you have fluid around your lungs or in your abdomen, or if certain lab tests are the only way to tell if you have the disease, you can't participate.I do not have severe numbness or pain in my hands or feet.There are no signs of air-filled spaces in the lungs.My blood pressure is under control.My kidney, lung function, blood counts, and clotting ability are normal.I have not had radiation therapy to my neck or chest.I do not have any serious wounds, ulcers, or broken bones that are not healing.My cancer is at stage IIIA with specific N2 lymph node involvement.I don't have any conditions besides lung cancer that increase my risk of bleeding.My heart functions well without severe symptoms.I am not currently undergoing intensity-modulated radiotherapy.I am not receiving preventive radiation therapy to the lymph nodes near my collarbone or opposite lung.I am not on any full-dose blood thinners.You are not allergic to Chinese hamster ovary cell products or other similar medicines.There are no signs of cavities in the body.I do not have any bleeding or clotting disorders.It has been over a week since my last biopsy or mediastinoscopy.I am not undergoing any major surgeries right now.I am not undergoing any major surgeries right now.You are not allergic to Chinese hamster ovary cell products or other genetically engineered human antibodies.
- Group 1: Group 2 (cisplatin, etoposide, radiotherapy, bevacizumab)
- Group 2: Group 3 (cisplatin, etoposide, radiotherapy, bevacizumab)
- Group 3: Group 1 (cisplatin, etoposide, radiotherapy)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any slots available to join this research endeavor?
"As per the information available on clinicaltrials.gov, this medical study is not actively taking partcipants at present. It was first posted in June 2006 and last updated just over a month ago; however, there are 4,747 other trials still recruiting patients right now."
How many individuals are partaking in this clinical investigation?
"This medical trial is not presently looking for volunteers. The research, which was first posted on June 15th 2006 and last updated November 16th 2022, has concluded its recruitment period. If you are searching other studies, there currently exists 3126 trials actively seeking participants with lung cancer as well as 1621 clinical trails involving Bevacizumab that are recruiting patients."
To what extent can Bevacizumab be detrimental to a human's health?
"Bevacizumab's safety has been assessed and found to be satisfactory, hence why it received a rating of 2. This is because the drug is currently being tested in Phase 2 trials with data confirming its security but not yet demonstrating efficacy."
Is Bevacizumab being tested in other clinical trials?
"In 1997, the City of Hope Comprehensive Cancer Centre was the first to study bevacizumab. As of 2021, there has been a total of 3410 clinical trials completed with 1621 now actively recruiting participants - many based in Olympia Washington."
How many centers are overseeing this trial?
"Recruitment for this clinical trial is taking place at Providence - Saint Peter Hospital in Olympia, Washington, Hutchinson Regional Medical Center in Hutchinson, Kansas and Audie L Murphy VA Hospital in San Antonio, Texas. Additionally there are 65 other sites across the United States where recruitment is being conducted."
To what extent does Bevacizumab assist in the treatment of various diseases?
"Bevacizumab is primarily used to target recurrent cervical cancer, but it can also prove effective against metastatic bladder cancer, prostate cancer and other advanced malignancies."
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