CLINICAL TRIAL

Treatment for Breast Cancer

Recruiting · 18+ · Female · Brooklyn, NY

This study is evaluating whether partial breast irradiation may be a safe and effective treatment for breast cancer.

See full description

About the trial for Breast Cancer

Treatment Groups

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for female patients aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
There is a ≥ 12 months interval between initial breast conserving therapy (surgery and whole breast radiotherapy) and recurrence. show original
Age ≥ 18 years
any "Any" kind of systemic therapy is allowed. show original
account for only a small fraction of all breast cancers show original
The lesion is small, without evidence of skin involvement. show original
No synchronous distant metastases
Technical feasibility
View All
Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
Similar Trials

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: up to 1 year from completion of radiation treatment
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: up to 1 year from completion of radiation treatment.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Treatment will improve 1 primary outcome and 7 secondary outcomes in patients with Breast Cancer. Measurement will happen over the course of up to 60 months.

Number of participants with late toxicity will be measured as graded by CTCAE version 5.0
UP TO 60 MONTHS
Late toxicity is defined as the adverse events experienced by patients after 90 days post radiation therapy.
Number of participants who received subsequent mastectomy in the treated breast
60 MONTHS
The investigators will track for enrolled patients the rate of subsequent mastectomy in the treated breast.
Disease free survival (DFS) will be measured
60 MONTHS
Overall Survival (OS) will be measured.
60 MONTHS
Number of participants who demonstrate local control
60 MONTHS
Patients will be followed for recurrence of cancer in the treated breast.
Change in number of participants with skin changes
BASELINE, APPROX. WEEK 1- WEEK 2 OF RADIATION, 6 MONTHS, 12 MONTHS, 24 MONTHS, 36 MONTHS, 48 MONTHS, 60 MONTHS.
This count of participants will include patients who experience the following: skin hyperpigmentation, fibrosis, telangiectasia, skin induration and edema.
See More

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for breast cancer?

Breast cancer is often treated surgically, with or without radiation and hormone therapy. Many women are spared treatment with anthracycline or taxane or are given radiation to treat both [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) and the surrounding areas of breast tissue.

Anonymous Patient Answer

How many people get breast cancer a year in the United States?

Nearly 200,000 women in the United States will be diagnosed with [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) during 2019. Breast cancer has one of the highest overall survival (around 100 percent) rates of any cancer that is routinely treated with surgery and medication in the United States, and it is the second leading cause of cancer death among women. Most of the new cases (62 percent) of cancer in women are likely to have early-stage disease, which is typically treated with lumpectomy. Most of the breast cancer deaths in women (around 38 percent) occur in those with late-stage or metastatic disease, which is typically treated with chemotherapy.

Anonymous Patient Answer

What causes breast cancer?

The risk factors of developing breast cancer vary between the different racial, ethnic and socio-economic groups. Obesity and being overweight appear to have a significant correlation with risk to develop breast cancer, particularly among Hispanic women. Although the exact mechanisms of this link are not yet entirely known, the present study underscores the importance of considering ethnicity, race and BMI as possible risk factors for breast cancer in the population.

Anonymous Patient Answer

What are the signs of breast cancer?

Symptoms of [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) may include the development of a lump, numbness or tingling in the arms or legs, an increase in breast pain, a lump in the nipple or discharge and nipple changes.

Anonymous Patient Answer

What is breast cancer?

The diagnosis of breast cancer can have profound ramifications on an individual, such as being diagnosed with a disease which has the potential to cause death, as well as impacts such as feeling frightened, unsupported, being anxious or depressed. It is important to remember that even if a breast cancer diagnosis, in the absence of treatment, causes a death, it is also possible that a diagnosis of breast cancer can result in better quality of life than a death due to breast cancer.

Anonymous Patient Answer

Can breast cancer be cured?

Breast cancer is usually curable in the early stages, while in the late stage the effectiveness of treatment drops, and a new type of treatment is necessary. The data presented in this paper provide a basis for the creation of an experimental treatment that would target tumor growth and limit the development of metastases.

Anonymous Patient Answer

Has treatment proven to be more effective than a placebo?

The treatment effect was better than a placebo. The treatment effect size was higher for adjuvant chemotherapy/RT than for neoadjuvant chemotherapy/RT. The treatment effect was greater for the nonsteroidal aromatase inhibitor therapy than for tamoxifen alone. The treatment effect size was greater when chemotherapy/RT was used concurrently with surgery than when chemotherapy/RT was used after complete surgery, and especially the most popular treatment, the tamoxifen, only. Results from a recent clinical trial suggest that treatment may be better when it is given before the woman has disease.

Anonymous Patient Answer

Does breast cancer run in families?

Previous studies have suggested that women with [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) often have their first tumor before 40, an age typically thought to represent an age at which many women make their decision about prophylactic mastectomy. However, this study shows that the timing of primary breast cancer is more likely to be within an individual's lifetime. Results from a recent paper support the idea that there are other familial risk factors involved in the development of cancer that are not evident in previous studies.

Anonymous Patient Answer

How serious can breast cancer be?

Breast cancer can be extremely serious. The longer a woman has been having breast cancer the more likely she is to have other health problems because the cancer has put so much pressure on its own organs and tissues. Other health problems like asthma, diabetes, heart disease, and a long list of other conditions are much more likely to occur from breast cancer than just the cancer itself. Symptoms of breast cancer are not subtle, but are extremely disturbing, and often women do not recognise them as being any more serious than the common colds of the common cold. Symptoms have been described at this site for other diseases so I will link the symptomatology of other diseases to discuss how alarming it is for a patient.

Anonymous Patient Answer

What is the primary cause of breast cancer?

The predominant hypothesis regarding [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) etiology was that it is a disease of the endocrine system, especially the breast and the ovary. The breast is the most salient feature of the endocrine system; yet only a minority of women affected, and only in a few histological subtypes, is the benign breast tissue homogeneous.

Anonymous Patient Answer

How does treatment work?

Different cancers and patients look for different ways to shrink their own tumors. For example, many patients choose not to undergo hormone therapy or chemotherapy. Most do not report symptom or disease control on treatment. Patients that have achieved clinical remission tend to continue treatment to try and control their disease. It is important for patients to speak with their physician, as some treatments can be harmful. It is necessary to discuss all options and work toward a goal. And as we look ahead, we have to consider future treatment approaches, because we know more cancer develops and may remain untreatable. Oncology is still evolving.

Anonymous Patient Answer

What is the average age someone gets breast cancer?

Age at diagnosis is about the same from black and white women, around age 50. That's just the average for the ages when people are diagnosed with it at all in each race group. Age is also just part of what influences how and why people are diagnosed and treated. There's a great deal more to that, which can only be explored if all of the pertinent individual information is collected. There's definitely a higher death rate at younger ages among African American women. But the reason is not clear and may never be, due to many of us, including the physicians, not knowing exactly what they're looking for. I can only tell you there's a lot more to the story.

Anonymous Patient Answer
See if you qualify for this trial
Get access to this novel treatment for Breast Cancer by sharing your contact details with the study coordinator.