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Biomarker Sampling for Ovarian Cancer

N/A

Recruiting

Led By Amit Oza, M.D.

Research Sponsored by University Health Network, Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Histological diagnosis of stage III or IV high grade serous ovarian, tubal or primary peritoneal cancer

Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 10 years

Awards & highlights

Study Summary

This trial will collect samples from gynecological cancer patients to study biomarkers that could help guide treatment decisions.

Who is the study for?

This study is for adults with advanced high-grade serous ovarian, tubal, or primary peritoneal cancer. Participants must be in good physical condition (ECOG 0-1), have a life expectancy of at least 6 months, and be willing to provide tissue samples during surgery or from existing tumor archives.Check my eligibility

What is being tested?

The trial involves collecting blood, tumor tissue, ascites (fluid in the abdomen), and other fluids from patients to find biomarkers that could help guide future treatment decisions. The collected data may also inform the patient's current treatment plan.See study design

What are the potential side effects?

Since this trial focuses on sample collection rather than drug testing, typical medication side effects are not expected. However, procedures like blood draws and biopsies can cause discomfort, bruising, infection risk at the puncture site.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with advanced high grade serous ovarian, tubal, or peritoneal cancer.

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I am fully active or can carry out light work.

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I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 10 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~10 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Genomic and immune signatures in terms of overall survival

Genomic and immune signatures in terms of progression free survival

Genomic and immune signatures in terms of resistance to treatments

+1 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Sample CollectionExperimental Treatment4 Interventions

The following samples may be collected during the study: Tumour tissue samples Blood samples Ascites samples Other fluids requiring drainage

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Blood sample collection

2014

Completed Phase 4

~16190

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor

1,468 Previous Clinical Trials

483,980 Total Patients Enrolled

5 Trials studying Gynecologic Cancers

898 Patients Enrolled for Gynecologic Cancers

Amit Oza, M.D.Principal InvestigatorPrincess Margaret Cancer Centre

10 Previous Clinical Trials

821 Total Patients Enrolled

1 Trials studying Gynecologic Cancers

500 Patients Enrolled for Gynecologic Cancers

Media Library

Tumour tissue collection Clinical Trial Eligibility Overview. Trial Name: NCT03419689 — N/A

Gynecologic Cancers Research Study Groups: Sample Collection

Gynecologic Cancers Clinical Trial 2023: Tumour tissue collection Highlights & Side Effects. Trial Name: NCT03419689 — N/A

Tumour tissue collection 2023 Treatment Timeline for Medical Study. Trial Name: NCT03419689 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the geographic locations that this clinical experimentation is taking place in?

"At the moment, patients are being recruited from 6 trial sites located in Ottawa, London and Barrie as well as 3 other locales. To reduce travel-related stressors, it is optimal to choose a clinic near your residence if you decide to join this clinical trial."

Answered by AI

Are there vacancies open for participants in the clinical trial?

"According to the information on clinicaltrials.gov, this medical research is actively recruiting candidates for participation. This trial was initially made available on August 1st 2018 and has been recently updated on December 10th 2021."

Answered by AI

Could you provide a tally of the participants recruited into this trial?

"Affirmative. Per the information on clinicaltrials.gov, this medical trial has been actively recruiting since January 8th 2018 and was recently updated in December 2021; it is hoped that a total of 510 participants will be enrolled across 6 distinct medical centres."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Study Looking at Biomarkers in Ovarian Cancer

2018. "Study Looking at Biomarkers in Ovarian Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03419689.