Dexamethasone for Ureteral Stent Syndrome
(DUSTS Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are taking strong CYP3A4 inducers or inhibitors within two weeks of screening or if you use chronic opioid analgesics.
Is Dexamethasone safe for humans?
How is the drug dexamethasone unique for treating ureteral stent syndrome?
Dexamethasone is unique for treating ureteral stent syndrome because it is a corticosteroid that can help reduce inflammation and relieve symptoms associated with ureteral obstruction, which is not a standard approach for managing stent-related symptoms. This anti-inflammatory effect can improve comfort and potentially avoid more invasive procedures.678910
What is the purpose of this trial?
The purpose of this study to learn if high-dose dexamethasone, a type of long-acting steroid, works to decrease urinary symptoms and pain after ureteroscopy and stent placement for kidney stones. The main question it aims to answer is:1) Does high-dose steroid change the quality of life score on day 2 after surgeryResearchers will compare high-dose of dexamethasone (20 mg) to a standard dose of dexamethasone (4 mg) to see if a higher dose of the drug will help with urinary symptoms and painParticipants will:1. randomly receive 20 mg or 4 mg of dexamethasone (20 mg) at the time of surgery2. fill out a questionnaire day 1 and day 2 after surgery3. fill out a medication diary for one week after surgery4. visit the clinic on day 2 after surgery for checkup5. visit the clinic on day 4-7 after surgery for check up
Research Team
Monica Morgan, MD
Principal Investigator
The Methodist Hospital Research Institute
Eligibility Criteria
This trial is for individuals experiencing urinary symptoms and pain after ureteroscopy with stent placement due to kidney stones. Participants must be suitable for high-dose steroid treatment, but specific inclusion criteria are not provided here.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either 20 mg or 4 mg of dexamethasone at the time of surgery
Postoperative Monitoring
Participants fill out questionnaires and medication diaries, and have follow-up visits for stent removal and monitoring of blood glucose levels
Follow-up
Participants are monitored for adverse events and quality of life, with a final follow-up call on day 30
Treatment Details
Interventions
- Dexamethasone
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Methodist Hospital Research Institute
Lead Sponsor