50 Participants Needed

Wild Blueberries for Joint Pain

AB
Overseen ByArpita Basu
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Nevada, Las Vegas

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether eating wild blueberries can improve gut health, reduce inflammation, and enhance joint function. Participants will consume either 25g of freeze-dried wild blueberries or a placebo powder daily for 12 weeks, with a break in between. It suits adults with arthritis affecting multiple joints or the knees. As an unphased trial, this study offers a unique opportunity to contribute to scientific understanding and potentially improve personal health.

Do I have to stop taking my current medications for the trial?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are on oral corticosteroid therapy of 5 mg/day or more. It's best to discuss your medications with the trial team.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that wild blueberries are likely safe to eat and may help reduce inflammation and protect joints. Some studies suggest that consuming wild blueberries could benefit conditions like osteoarthritis. While most people can eat blueberries without issues, a few might experience mild side effects, such as an upset stomach, especially if consumed in large quantities. However, these side effects are uncommon. Overall, evidence suggests that wild blueberries are a safe choice for most people.12345

Why are researchers excited about this trial?

Unlike standard treatments for joint pain, which often include NSAIDs or corticosteroids, wild blueberries offer a natural alternative. Researchers are excited about wild blueberries because they are rich in polyphenols, natural compounds believed to reduce inflammation and oxidative stress, potentially alleviating joint pain. This treatment is also appealing because it involves consuming a simple, daily dose of freeze-dried wild blueberries, making it a non-invasive option with a delicious twist.

What evidence suggests that wild blueberries might be an effective treatment for joint pain?

This trial will compare the effects of wild blueberries with a placebo on joint pain. Research has shown that adding whole blueberries to the diet can reduce pain and swelling. In one study involving individuals with knee osteoarthritis, a daily serving of freeze-dried blueberries improved joint health. Early results suggest that blueberries might naturally reduce inflammation, enhancing joint function. These benefits likely come from polyphenols, natural substances in blueberries known for their anti-inflammatory effects. Overall, blueberries appear promising for supporting joint health and reducing inflammation.16789

Are You a Good Fit for This Trial?

Adults with documented multi-joint or knee arthritis can participate in this trial. They will be consuming either wild blueberries or a placebo for 12 weeks to study the effects on gut health, inflammation, and joint function.

Inclusion Criteria

I have arthritis in multiple joints or in my knees.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants consume 25g freeze-dried wild blueberries or placebo powder daily

12 weeks

Washout

A 2-week washout phase between treatment periods

2 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Placebo
  • Wild Blueberries
Trial Overview The trial is testing if eating freeze-dried wild blueberries affects the gut microbiome, inflammation levels in the blood, and improves joint function compared to a placebo over a period of 12 weeks with an additional 2-week washout phase.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Wild blueberriesExperimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Nevada, Las Vegas

Lead Sponsor

Trials
81
Recruited
14,700+

Wild Blueberry Association of North America (WBANA)

Collaborator

Trials
5
Recruited
290+

Oklahoma Medical Research Foundation

Collaborator

Trials
24
Recruited
8,400+

Citations

Anti-Inflammatory and Joint-Protective Effects of Blueberries in ...The incorporation of whole blueberries into diets reduced pain behaviors and inflammation. Conclusions: Overall, whole blueberries showed ...
New OMRF study asks whether blueberries can help ...It seeks to build from a 2019 study of people with knee osteoarthritis who consumed a daily serving of about 1½ ounces of freeze-dried blueberry ...
Blueberries studied as natural arthritis treatment by ...The study follows earlier research suggesting berries may benefit joint health — and possibly more.
NCT06828159 | Dietary Wild Blueberries and Joint HealthThe goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in ...
Wild blueberry (Vaccinium Angustifolium) consumption ...Results of this study suggest that wild blueberry consumption exerts an overall anti-inflammatory effect in the OZR, a model of the metabolic ...
The effect of wild blueberry ( Vaccinium angustifolium ) ...The present study examined the effect of wild blueberries on oxidative stress, the inflammatory response and DNA damage associated with exercise in ...
The Effect of Wild Blueberry Consumption on the Inflammatory ...The reported findings suggest that ingestion of a tart cherry juice blend may decrease some of the symptoms of exercise induced muscle damage, ...
Blueberry - Uses, Side Effects, and MoreLearn more about Blueberry uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Blueberry.
Wild Blueberries + Inflammation and Joint PainThe purpose of this study is to find out about the effects of blueberry intake on blood markers of inflammation and fecal bacteria and to examine how these ...
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