Obecabtagene Autoleucel for Acute Lymphoblastic Leukemia
What You Need to Know Before You Apply
What is the purpose of this trial?
The researchers are doing this study to find out whether obecabtagene autoleucel (obe-cel) is an effective treatment for people with B-cell acute lymphoblastic leukemia (ALL) that is in complete remission (CR, meaning all signs of cancer are gone) with no measurable residual disease (MRD-negative, meaning there are no detectable cancer cells). Participants in this study will have received past treatment for their B-cell ALL, and their disease will be in MRD-negative CR for the first time (first MRD-negative CR).
Who Is on the Research Team?
Jae Park, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Are You a Good Fit for This Trial?
This trial is for adults aged 40 and above with B-cell acute lymphoblastic leukemia (ALL) in complete remission but still at high risk. It includes those who've had specific prior treatments like Inotuzumab or blinatumomab, and are now MRD-negative. Younger patients (30-39) with high-risk health issues may also qualify.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive obe-cel infusion for treatment of B-cell acute lymphoblastic leukemia
Follow-up
Participants are monitored for relapse free survival and event free survival
What Are the Treatments Tested in This Trial?
Interventions
- Obecabtagene Autoleucel
Trial Overview
The study tests obecabtagene autoleucel (obe-cel), a new therapy for B-cell ALL that's in remission without detectable cancer cells. Participants must have responded to past treatment and be within four months of their initial anti-leukemic therapy when joining the study.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
is an exploratory cohort that will enroll Philadelphia chromosome positive patients
will enroll Philadelphia chromosome negative patients
Find a Clinic Near You
Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor
Autolus Limited
Industry Sponsor
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