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Longitudinal Assessments for Depression

N/A

Recruiting

Led By Kathryn Cullen, MD

Research Sponsored by University of Minnesota

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 months or 12 months

Awards & highlights

Study Summary

This trial aims to investigate why some people act impulsively when experiencing negative emotions, known as negative urgency, and how this is related to brain cell communication in adolescents aged 13-21 with depression and

Who is the study for?

This trial is for adolescents aged 13-18 with depression and suicidal thoughts or behaviors. They must be able to communicate in English, provide consent (or have a guardian do so if under 18), and not have a history of suicide attempts if only experiencing suicidal thoughts.Check my eligibility

What is being tested?

The study tests how brain cell networks communicate during negative urgency using transcranial magnetic stimulation with EEG. It examines whether cortical inhibition relates to impulsivity in depressed teens, comparing those with suicidal behavior to those with thoughts only over time.See study design

What are the potential side effects?

Transcranial magnetic stimulation is generally considered safe but may cause discomfort at the stimulation site, headache, lightheadedness, or seizures in very rare cases.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 months or 12 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 months or 12 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months or 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Long-interval intracortical inhibition (LICI) - 12 months

Long-interval intracortical inhibition (LICI) - 6 months

Long-interval intracortical inhibition (LICI) - baseline

+3 more

Secondary outcome measures

Change in long-interval intracortical inhibition (LICI)

Change in negative urgency

Trial Design

1Treatment groups

Experimental Treatment

Group I: Longitudinal AssessmentsExperimental Treatment1 Intervention

Participants in both groups (Dep/SI and Dep/SB) will undergo identical assessments at baseline, 6 months, and 12 months. Assessments will include clinical interviews and rating scales, questionnaires (including a self-report scale of negative urgency), and single-/paired-pulse transcranial magnetic stimulation (sp/ppTMS) measurement of cortical inhibition.

Do I qualify?Apply below to find out

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Who is running the clinical trial?

University of MinnesotaLead Sponsor

1,381 Previous Clinical Trials

1,551,204 Total Patients Enrolled

31 Trials studying Depression

5,463 Patients Enrolled for Depression

National Institute of Mental Health (NIMH)NIH

2,786 Previous Clinical Trials

2,689,612 Total Patients Enrolled

666 Trials studying Depression

251,485 Patients Enrolled for Depression

Kathryn Cullen, MDPrincipal InvestigatorUniversity of Minnesota

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the age threshold of this medical study inclusive of individuals who have surpassed 75 years?

"The study is seeking individuals aged 13 to 20 years old for participation."

Answered by AI

What is the upper threshold for the number of individuals enrolled in this medical study?

"Indeed, as per details from clinicaltrials.gov, this investigation is actively enrolling subjects. The trial was first disclosed on February 28th, 2024 and underwent its latest update on April 2nd, 2024. It aims to recruit a total of 80 participants at one designated site."

Answered by AI

Are there any available vacancies for participants in this clinical trial?

"Based on information from clinicaltrials.gov, this research is presently seeking eligible individuals. The trial's initial posting date was 2/28/2024, with the most recent update made on 4/2/2024."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior

2024. "Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05652153.