Zanzalintinib for Cancer

Overseen By Luana Sousa, MD

Age: 18+

Sex: Any

Trial Phase: Phase 2

Sponsor: M.D. Anderson Cancer Center

Must not be taking: Oral anticoagulants, Platelet inhibitors

Disqualifiers: Active CNS disease, Uncontrolled hypertension, Recent stroke, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: 28

Duration: 12 months

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this clinical research study is to learn if zanzalintinib can help to control recurrent/metastatic ONB. The safety of zanzalintinib will also be studied.

Who Is on the Research Team?

Luana Sousa, MD

Principal Investigator

UT MD Anderson

Are You a Good Fit for This Trial?

Inclusion Criteria

I am not pregnant right now.

I understand the study and have signed the consent form.

My blood, kidney, and liver tests show normal organ function.

Exclusion Criteria

I have not had radiation therapy for bone metastasis recently.

I do not have any serious or uncontrolled illnesses right now.

Subjects must not have known hypersensitivity to study drugs or related components

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive Zanzalintinib at a dose of 60 mg orally once daily in a 28-day cycle

12 months

Monthly visits for each 28-day cycle

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Zanzalintinib

How Is the Trial Designed?

Group I: Phase 2: Treatment with Zanzalintinib Experimental Treatment 1 Intervention

Participants will be enrolled into a single cohort (N=16). Enrolled participants will receive Zanzalintinib at a dose of 60 mg orally once daily in a 28-day cycle.

Who Is Running the Clinical Trial?

M.D. Anderson Cancer Center

Lead Sponsor

Trials

3,107

Recruited

1,813,000+