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Radiotherapy for Rectal Cancer (ROBIN Trial)
ROBIN Trial Summary
This trial studies rectal cancer, its treatment with radiotherapy, and its effects on the immune system.
ROBIN Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.ROBIN Trial Design
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Who is running the clinical trial?
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- I have had radiation therapy to my pelvic area before.My diagnosis is rectal adenocarcinoma.My rectal cancer has come back.I am not on antibiotics for an infection.I haven't taken high-dose immune-suppressing drugs in the last 2 weeks.I am fully active or can carry out light work.I am 18 years old or older.My rectal cancer can be surgically removed with a specific technique.My cancer has not spread to distant parts of my body.I am a woman who can have children, not pregnant, and agree to use birth control during the study.I have 4 or more large lymph nodes in my pelvis.My cancer is in an early but invasive stage.My rectal cancer cannot be surgically removed due to its attachment to nearby structures.My cancer has not spread to nearby large structures.I have not had chemotherapy or surgery for rectal cancer.I am not on any other cancer treatments or experimental drugs.I have not had radiation therapy to my pelvic area.
- Group 1: Single cohort
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the current size of the cohort for this experiment?
"Affirmative. Data accessible through clinicaltrials.gov confirms that this experiment is presently recruiting participants, having been initially published on May 22nd 2023 and last updated July 3rd 2023. 25 test subjects are being sought from 6 distinct medical facilities."
Is the current enrollment restricted to individuals over forty years old?
"This research is seeking volunteers who are aged between 18 and nonaginta years old."
Is it possible to register for this research project?
"Aspiring participants of this clinical trial must possess a diagnosis of colorectal cancer, and be between 18-90 years old. This study is graciously admitting up to 25 people in total."
Are there any vacancies available to take part in this research?
"Indeed, the data hosted on clinicaltrials.gov shows that this experimental study is currently in need of participants and was updated as recently as July 3rd 2023. 25 people are required to be recruited from 6 different medical centres."
What are the key aims of this clinical investigation?
"This trial is set to run for 6 weeks and will assess the number of research specimens obtained after radiation therapy. Secondary outcomes being measured are changes in enhancement kinetics from pre-treatment and post-treatment CTs, functional diffusion patterns from pre-treatment and post-treatment MRI scans, as well as immunological fitness related to radio-responsiveness via gamma-H2aX (aging) quantification. To do this, conventional radiomics methods combined with deep learning based radiomics (DLR) approaches will be applied in order extract detailed information on these parameters at each time point."
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