Solrikitug for COPD
(ZION Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
A Randomized, Double-blind, Placebo-controlled, Multiple Dose-Ranging Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Solrikitug in Participants with Chronic Obstructive Pulmonary Disease (COPD).
Will I have to stop taking my current medications?
The trial does not specify if you need to stop your current medications, but it requires that you have been on 2 or more inhaled maintenance medications for at least 3 months before screening. It seems likely you will continue your current medications during the trial.
How is the drug Solrikitug different from other COPD treatments?
Solrikitug is unique because it is a humanized monoclonal antibody that targets a specific protein involved in inflammation, which is different from other COPD treatments like roflumilast that work by inhibiting enzymes to reduce inflammation. This targeted approach may offer a new way to manage COPD symptoms by directly interfering with the inflammatory process.12345
What data supports the effectiveness of the drug Solrikitug for COPD?
While there is no direct data on Solrikitug, similar treatments like mepolizumab, which is also a monoclonal antibody, have shown benefits in reducing exacerbations in COPD patients with high levels of eosinophils (a type of white blood cell involved in inflammation). This suggests that targeting specific inflammatory pathways may be beneficial for certain COPD patients.678910
Who Is on the Research Team?
Andrew W Lee, MD
Principal Investigator
Vice President, Clinical Research
Are You a Good Fit for This Trial?
This trial is for adults aged 40-70 with COPD who experience symptoms (CAT Score ≥10), have been diagnosed for at least a year, and are on two or more inhaled meds. They must have certain levels of lung function and blood eosinophils as per GOLD Guidelines.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive solrikitug or placebo via subcutaneous injection over a 12-week period
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Solrikitug
Find a Clinic Near You
Who Is Running the Clinical Trial?
Uniquity One (UNI)
Lead Sponsor
DevPro Biopharma
Collaborator
DevPro Biopharma
Industry Sponsor