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Nebulized Furosemide for Coronavirus (FaST-1 Trial)

Phase 2 & 3
Waitlist Available
Led By John Muscedere, MD
Research Sponsored by Dr. John Muscedere
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 60 post enrollment
Awards & highlights

FaST-1 Trial Summary

This trial will study the effects of nebulized furosemide on pulmonary inflammation in patients with COVID-19 who are intubated and on mechanical ventilation.

Eligible Conditions
  • Coronavirus
  • Respiratory Failure

FaST-1 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 60 post enrollment
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 60 post enrollment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Improvement in pulmonary gas exchange
Requirement for mechanical ventilation
Secondary outcome measures
Adverse events
Duration of ICU Stay
Inhalation adverse events
+3 more
Other outcome measures
Cytokine levels
Electrolyte abnormalities
Serum levels of furosemide

FaST-1 Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Inhaled FurosemideExperimental Treatment1 Intervention
40 mg furosemide per dose, given by nebulization (4 mL of 10 mg/mL furosemide in 0.9% saline solution) over 30 mins four times daily (Q6H) for up to 28 days
Group II: Nebulized SalinePlacebo Group1 Intervention
Placebo, given by nebulization (4 mL of 0.9% saline solution) over 30 mins four times daily (Q.I.D.) for up to 28 days

Find a Location

Who is running the clinical trial?

Dr. John MuscedereLead Sponsor
3 Previous Clinical Trials
1,150 Total Patients Enrolled
Queen's UniversityLead Sponsor
362 Previous Clinical Trials
119,451 Total Patients Enrolled
University Health Network, TorontoOTHER
1,456 Previous Clinical Trials
482,833 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How can Nebulized Furosemide help patients?

"Nebulized Furosemide is commonly used to mitigate heart failure, but it can also be employed to reduce fluid retention in edema, acute pulmonary edema, and hypertensive disease."

Answered by AI

Why did researchers design this clinical trial in this way?

"The planned intervention will be measured for its efficacy in Baseline to day 28 time frame. The success of the trial will be judged by Improvement in pulmonary gas exchange. Additionally, secondary outcomes including Inhalation adverse events, Requirement for supplemental oxygen, and Duration of ICU Stay will also be monitored."

Answered by AI

Could you tell me how many hospitals are participating in this clinical trial?

"Currently, this study is accepting patients from University of Alberta in Edmonton, Alberta, Kingston Health Sciences Center in Kingston, Ontario, and Hôpital Maisonneuve-Rosemont in Montréal, Quebec. There are also 4 other potential locations for recruitment."

Answered by AI

Could I be a candidate for this medical research?

"The only patients who will be accepted into this study are those with covid-19 and between the ages of 18 and 100. Furthermore, no more than 640 people can join the trial."

Answered by AI

If a patient is below 25 years of age, can they still participate in this research?

"People aged 18 to 100 who meet the other specified inclusion criteria can apply to participate in this trial. There are 175 similar studies for people under 18 and 1145 for those over 65."

Answered by AI

Are there any other Nebulized Furosemide studies that have been completed?

"Nebulized Furosemide was first studied in 2015 at Gregorio Maranon Hospital. As of now, there have been a total of 110 completed studies with 16 more ongoing. The majority of these live studies are situated in Edmonton, Alberta."

Answered by AI

How many people can join this medical study at most?

"The information available on clinicaltrials.gov implies that the research team is actively seeking participants for this study. The trial was first posted on April 16th, 2021 and underwent its most recent edit on August 16th, 2022. This experiment requires 640 individuals from 4 distinct locations."

Answered by AI

Are there any available slots for patients in this trial?

"The clinical trial is recruiting patients at 4 locations, looking for a total of 640 individuals. The study was first posted on April 16th, 2021 and edited most recently on August 16th, 2022."

Answered by AI
~10 spots leftby Mar 2025