Extended Longevity Supplements for Aging

Overseen By Annie Prestrud, MD

Age: 18+

Sex: Any

Trial Phase: Phase 2

Sponsor: TruDiagnostic

Disqualifiers: Cancer, Cardiovascular disease, Hepatitis, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: Unknown

Duration: 3 months

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine if Extended Longevity supplements can significantly affect genetic aging rates. The supplements contain natural extracts such as Pinetonal and Thyvolve, derived from plants. The study seeks participants aged 55 to 75 with a healthy immune system and no recent history of cancer or major heart issues. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering participants an opportunity to contribute to groundbreaking longevity research.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Is there any evidence suggesting that the Extended Longevity supplements are likely to be safe for humans?

Research has shown that the ingredients in the Extended Longevity supplements are generally safe. However, a study in Italy found 23 serious reactions among 110 reports of herbal supplement use. This indicates that while most people tolerate these supplements well, a small risk of side effects exists.

The supplements contain natural ingredients derived from plants. Past research has demonstrated these ingredients to be safe and effective for anti-aging. Consulting a healthcare provider before starting any new supplement is always advisable. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Unlike the standard of care for aging, which often includes synthetic drugs or invasive procedures, the Extended Longevity supplements are derived entirely from natural plant extracts. These extracts, like Pinetonal and Thyvolve, offer a unique approach by targeting cellular health and longevity pathways such as autophagy and inflammation reduction. Researchers are excited because this treatment could provide a holistic, less intrusive alternative with fewer side effects, potentially revolutionizing how we manage aging.

What evidence suggests that the Extended Longevity supplements could be effective for aging?

Research has shown that the ingredients in the Extended Longevity supplements, which participants in this trial will receive, may help with aging-related issues like hair thinning and shedding. For example, studies have found that these extracts can reduce hair loss and promote new hair growth. In trials, participants noticed improved hair health within a few months. While the main goal is to affect the biological age of cells, current data suggests these supplements also assist with other aging-related conditions. It is important to note that the impact on biological age remains under study, but early signs are promising. ^{3 4 6 7 8}

Are You a Good Fit for This Trial?

Inclusion Criteria

8 Men and 7 Women

Must between 55-75 years old

Patient must be able to comply with treatment plan and laboratory tests

Exclusion Criteria

Presence of active infection

You have a serious heart or stroke condition that is not stable or under control.

You had a mini-stroke within the past 6 months.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the Extended Longevity Protocol treatment to assess its impact on epigenetic aging

3 months

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Extracts found in the Extended Longevity supplements

How Is the Trial Designed?

Group I: Extracts Experimental Treatment 1 Intervention

The ingredients found in these serums are all naturally occurring ingredients extracted from a variety of plant species: Pinetonal, Thyvolve, Telogenic, Sentophagy, Inflasolve, Stemegenis, and CMEnhance

Who Is Running the Clinical Trial?

TruDiagnostic

Lead Sponsor

Trials

12

Recruited

490+

Founded

2019

Headquarters

Lexington, United States

Known For

Epigenetic testing

Published Research Related to This Trial

A novel composition of plant extracts was developed that targets multiple hallmarks of aging, showing promising results in increasing cellular lifespan and enhancing antioxidant defenses in both cell cultures and living organisms.

In a 3-month randomized controlled trial with healthy volunteers, this combination significantly improved antioxidant capacity, suggesting that such natural compound interventions can effectively enhance healthspan and overall well-being.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Antioxidant and Antiaging Properties of a Novel Synergistic Nutraceutical Complex: Readouts from an In Cellulo Study and an In Vivo Prospective, Randomized Trial. Athanasopoulou, S., Kapetanou, M., Magouritsas, MG., et al.[2022]

A study analyzing 110 reports of adverse reactions to herbal dietary supplements in Italy found that 23 serious reactions occurred, with 21 requiring hospitalization, highlighting significant safety concerns regarding these products.

Dermatological and cardiovascular issues were the most common reactions, and 9 out of 10 serious hepatic reactions were reported, indicating that the quality and supervision of these supplements are critical for consumer safety.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Suspected adverse reactions to performance enhancing dietary supplements: Spontaneous reports from the Italian phytovigilance system. Ippoliti, I., Menniti-Ippolito, F., Mazzanti, G., et al.[2021]

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11943383/

Hair Longevity—Evidence for a Multifactorial Holistic ... For pattern hair loss and hair thinning, results will be seen typically between 4 and 12 months of use. Where hair shedding is measured [103,127], the lessening ...

2. sciencedirect.com sciencedirect.com/science/article/pii/S2589537021002583

Safety and efficacy of ALRV5XR in women with ... ALRV5XR displayed a multi-fold improved efficacy and response rate when compared to published trials of standard therapy. Progressive acceleration of TH ...

3. clinicaltrials.gov clinicaltrials.gov/study/NCT05296993

Study Details | Safety & Efficacy of Extended Longevity Protocol Summary results information includes participant flow, baseline characteristics, outcome measures, and adverse events (including serious adverse events). ... The ...

4. isrctn.com isrctn.com/ISRCTN84821936

ISRCTN84821936: Evaluation of the efficacy and safety of ... In particular, the study evaluates product effectiveness in increasing the number of hairs in the anagen phase, reducing hair shedding and follicular ...

5. researchgate.net researchgate.net/publication/389746425_Hair_Longevity-Evidence_for_a_Multifactorial_Holistic_Approach_to_Managing_Hair_Aging_Changes

(PDF) Hair Longevity—Evidence for a Multifactorial Holistic ... This review examines the evidence for the more holistic approach to addressing unwanted hair loss, which includes nutrition, lifestyle, stress ...

6. withpower.com withpower.com/trial/phase-2-aging-4-2021-387f0

Extended Longevity Supplements for Aging A study analyzing 110 reports of adverse reactions to herbal dietary supplements in Italy found that 23 serious reactions occurred, with 21 requiring ...

7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC9086005/

Antiaging agents: safe interventions to slow aging and healthy ... The data confirmed that the compound is safe and effective. ... data unreliable, especially when assessing the effects of modified aging.

8. dsm-firmenich.com dsm-firmenich.com/en/businesses/perfumery-beauty/beauty-care/products/eterwell-hair.html

ETERWELL™ HAIR It's no surprise that 58% of global consumers say hair aging is their biggest concern. ... Download a Safety Data Sheet (SDS) for this product. Download SDS.