Extended Longevity Supplements for Aging

Overseen By Annie Prestrud, MD

Age: 18+

Sex: Any

Trial Phase: Phase 2

Sponsor: TruDiagnostic

Disqualifiers: Cancer, Cardiovascular disease, Hepatitis, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: Unknown

Duration: 3 months

15 Participants Needed

Trial Summary

What is the purpose of this trial?

This trial is testing a treatment plan called the Extended Longevity Protocol, which aims to slow down aging. It focuses on 15 healthy individuals to see if it can make them age more slowly and stay healthier. The protocol works by addressing nine different factors that contribute to aging.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What data supports the effectiveness of the Extended Longevity supplements treatment?

Research suggests that while individual dietary supplements do not enhance health or longevity, complex combinations of supplements might mimic the benefits of micronutrients found in fruits and vegetables. However, studies in mice showed no significant lifespan increase from these combinations, and some even decreased lifespan, indicating that the effectiveness of such treatments remains uncertain. ^{1 2 3 4 5}

Is the Extended Longevity Supplement generally safe for humans?

There are safety concerns with herbal dietary supplements, including those used for performance enhancement and containing Serenoa repens, as they have been linked to serious adverse reactions like liver issues, cardiovascular problems, and other health risks. These supplements often lack proper regulation and expert supervision, which can lead to harmful effects. ^{6 7 8 9 10}

How is the Extended Longevity Supplements treatment different from other treatments for aging?

The Extended Longevity Supplements treatment is unique because it uses a combination of natural plant extracts that work together to target multiple aspects of aging, such as reducing oxidative stress and preserving DNA health, which is not typically addressed by single supplements. This approach aims to improve overall health and extend the period of life spent in good health, known as healthspan. ^{3 11 12 13 14}

Eligibility Criteria

Inclusion Criteria

8 Men and 7 Women

Must between 55-75 years old

Patient must be able to comply with treatment plan and laboratory tests

Exclusion Criteria

Presence of active infection

You have a serious heart or stroke condition that is not stable or under control.

You had a mini-stroke within the past 6 months.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the Extended Longevity Protocol treatment to assess its impact on epigenetic aging

3 months

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Extracts found in the Extended Longevity supplements

Participant Groups

Group I: Extracts Experimental Treatment 1 Intervention

The ingredients found in these serums are all naturally occurring ingredients extracted from a variety of plant species: Pinetonal, Thyvolve, Telogenic, Sentophagy, Inflasolve, Stemegenis, and CMEnhance

Who Is Running the Clinical Trial?

TruDiagnostic

Lead Sponsor

Trials

12

Recruited

490+

Founded

2019

Headquarters

Lexington, United States

Known For

Epigenetic testing

Findings from Research

A study analyzing 110 reports of adverse reactions to herbal dietary supplements in Italy found that 23 serious reactions occurred, with 21 requiring hospitalization, highlighting significant safety concerns regarding these products.

Dermatological and cardiovascular issues were the most common reactions, and 9 out of 10 serious hepatic reactions were reported, indicating that the quality and supervision of these supplements are critical for consumer safety.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Suspected adverse reactions to performance enhancing dietary supplements: Spontaneous reports from the Italian phytovigilance system. Ippoliti, I., Menniti-Ippolito, F., Mazzanti, G., et al.[2021]

A novel composition of plant extracts was developed that targets multiple hallmarks of aging, showing promising results in increasing cellular lifespan and enhancing antioxidant defenses in both cell cultures and living organisms.

In a 3-month randomized controlled trial with healthy volunteers, this combination significantly improved antioxidant capacity, suggesting that such natural compound interventions can effectively enhance healthspan and overall well-being.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Antioxidant and Antiaging Properties of a Novel Synergistic Nutraceutical Complex: Readouts from an In Cellulo Study and an In Vivo Prospective, Randomized Trial. Athanasopoulou, S., Kapetanou, M., Magouritsas, MG., et al.[2022]

References

1. United States pubmed.ncbi.nlm.nih.gov

Finally, a Regimen to Extend Human Life Expectancy. [2018]

2. England pubmed.ncbi.nlm.nih.gov

The road ahead for health and lifespan interventions. [2021]

3. Netherlands pubmed.ncbi.nlm.nih.gov

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice. [2021]

4. United States pubmed.ncbi.nlm.nih.gov

Healthspan Pharmacology. [2019]

5. England pubmed.ncbi.nlm.nih.gov

Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu. [2021]

6. Italy pubmed.ncbi.nlm.nih.gov

[Herbs on the Internet: risky information]. [2013]

7. England pubmed.ncbi.nlm.nih.gov

A descriptive study of commercial herbal dietary supplements used for dyslipidemia-Sales data and suspected adverse reactions. [2022]

8. United States pubmed.ncbi.nlm.nih.gov

Narrative Review: The FDA's Perfunctory Approach of Dietary Supplement Regulations Giving Rise to Copious Reports of Adverse Events. [2023]

9. England pubmed.ncbi.nlm.nih.gov

Suspected adverse reactions to performance enhancing dietary supplements: Spontaneous reports from the Italian phytovigilance system. [2021]

10. England pubmed.ncbi.nlm.nih.gov

Suspected adverse reactions to medications and food supplements containing Serenoa repens: A worldwide analysis of pharmacovigilance and phytovigilance spontaneous reports. [2023]

11. England pubmed.ncbi.nlm.nih.gov

Natural compounds with anti-ageing activity. [2013]

12. United States pubmed.ncbi.nlm.nih.gov

A complex dietary supplement extends longevity of mice. [2019]

13. Switzerland pubmed.ncbi.nlm.nih.gov

Antioxidant and Antiaging Properties of a Novel Synergistic Nutraceutical Complex: Readouts from an In Cellulo Study and an In Vivo Prospective, Randomized Trial. [2022]

14. England pubmed.ncbi.nlm.nih.gov

Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity. [2023]