TR-002 for Pancreatic Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine the safest dose and identify side effects of a new chemotherapy drug, TR-002, for individuals with advanced pancreatic cancer that cannot be surgically removed and has stopped responding to other treatments. TR-002 may help prevent tumor cells from growing and spreading. The trial seeks participants with pancreatic cancer that has spread and is no longer responding to standard treatments. As a Phase 1 trial, this research focuses on understanding how TR-002 works in people, offering participants the opportunity to be among the first to receive this new treatment.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor to get specific guidance based on your situation.
Is there any evidence suggesting that TR-002 is likely to be safe for humans?
Research is testing TR-002 for safety in people with advanced pancreatic cancer and other solid tumors. As an early trial, limited information exists about its safety in humans. However, such trials are designed to closely monitor participants' responses to the treatment.
Doctors in these trials look for side effects and assess how well participants tolerate the treatment. TR-002 is administered to a small group to determine the best dose and identify any major issues. Participants receive close monitoring for unwanted side effects.
If TR-002 were unsafe, the trial would stop. The ongoing status of the trial suggests that TR-002 might be well-tolerated so far. However, joining a trial involves risks, so discussing any concerns with the doctors is important.12345Why do researchers think this study treatment might be promising?
Unlike the standard treatments for pancreatic cancer, which often include chemotherapy drugs like gemcitabine and nab-paclitaxel, TR-002 offers a new approach by being administered intravenously on a specific schedule designed to maximize its impact. Researchers are excited about TR-002 because it has a unique mechanism that could potentially target cancer cells more effectively, while minimizing damage to healthy cells. This precise delivery method and innovative mechanism of action set TR-002 apart, offering hope for improved outcomes in a condition known for its challenging prognosis.
What evidence suggests that TR-002 might be an effective treatment for pancreatic cancer?
Research has shown that TR-002, the investigational treatment in this trial, stops cancer cells from growing and spreading. This is crucial for treating challenging cases like advanced pancreatic cancer, which often resists standard treatments. Early results suggest that TR-002 might help by targeting and killing these stubborn cancer cells. Although specific data on TR-002's effectiveness for pancreatic cancer is limited, it functions similarly to other chemotherapy drugs that have successfully fought cancer. The hope is that TR-002 will offer a new option for patients with limited choices.26789
Who Is on the Research Team?
Edward J Kim, MD
Principal Investigator
University of California, Davis
Are You a Good Fit for This Trial?
This trial is for patients with advanced solid tumors or pancreatic adenocarcinoma that has spread and cannot be removed by surgery. Participants must have a type of cancer that hasn't responded to previous treatments. Specific eligibility criteria are not provided, but typically include factors like age, health status, and prior treatment history.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive TR-002 intravenously on days 1, 8, 15, and 22 of each 28-day cycle
Follow-up
Participants are monitored for safety and effectiveness after treatment completion
What Are the Treatments Tested in This Trial?
Interventions
- TR-002
Trial Overview
The trial is testing TR-002, a chemotherapy drug intended to kill or stop the growth and spread of tumor cells. This phase I study aims to determine the safest dose with the fewest side effects for treating advanced or metastatic solid tumors and refractory pancreatic adenocarcinoma.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients receive TR-002 IV, over 1 hour, on days 1, 8, 15 and 22 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo echocardiography or MUGA scan during screening and undergo CT scan, MRI, tumor biopsy and blood sample collection throughout the study.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Davis
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
Citations
1.
trial.medpath.com
trial.medpath.com/clinical-trial/c02619bb24cff752/nct07189195-tr-002-treatment-advanced-metastatic-solid-tumors-pancreatic-adenocarcinomaTR-002 for the Treatment of Advanced, Unresectable or ...
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