THC for Cannabis Use

(HIGH-CAP Trial)

Overseen By Ziva Cooper, PhD

Age: 18 - 65

Sex: Any

Trial Phase: Phase 1

Sponsor: University of California, Los Angeles

Must not be taking: Prescription analgesics, others

Disqualifiers: Substance use disorder, Psychiatric illness, Pregnancy, others

Compensation: Varies

Number of Visits: Unknown

Duration: 3 hours per session

30 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.

Are You a Good Fit for This Trial?

This trial is for adults aged 21-55 who smoke cannabis nearly every day but aren't looking to treat their usage. They should be able to do all study tasks, have a BMI of 18.5 - 34kg/m2, and use contraception if needed. Pregnant or breastfeeding women can't join.

Inclusion Criteria

I am a man or a woman not pregnant or breastfeeding, aged 21-55.

I smoke cannabis almost every day.

I can participate in all required study activities.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive smoked cannabis with varying THC doses and placebo to assess acute effects

3 hours per session

Multiple sessions (in-person)

Abstinence

Participants undergo a brief period of abstinence to assess changes in cannabis effects

1-2 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• High Potency Cannabis

Trial Overview The study is testing the effects of smoked cannabis by comparing high dose THC, low dose THC, and placebo in participants during normal use and after a short break from using cannabis.

How Is the Trial Designed?

Group I: Low dose THC Active Control 1 Intervention

50 mg THC

Group II: High dose THC Active Control 1 Intervention

100 mg THC

Group III: Placebo Comparator: Placebo Placebo Group 1 Intervention

0 mg THC

Who Is Running the Clinical Trial?

University of California, Los Angeles

Lead Sponsor

Trials

1,594

Recruited

10,430,000+