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Ursodiol + Chemotherapy + Bevacizumab for Colorectal Cancer
Study Summary
This trial is studying the side effects and best dose of the drug ursodiol when given together with combination chemotherapy (leucovorin calcium, fluorouracil, and oxaliplatin) and bevacizumab in treating patients with stage IV colorectal cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2020 Phase 1 & 2 trial • 88 Patients • NCT02012296Trial Design
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- I have not taken systemic steroids in the last 7 days.I have lost more than 10% of my weight in the past 6 months.I have advanced colorectal cancer confirmed by a biopsy.I finished my last treatment 3 weeks ago and have recovered from side-effects.I can carry out normal activities with minimal symptoms.I do not have any severe health or mental conditions that make treatment risky.I am currently breastfeeding.I am not pregnant and can use birth control.
- Group 1: Treatment (ursodiol, combination chemotherapy, bevacizumab)
- Approved for 5 Other Conditions - This treatment demonstrated efficacy for 5 other conditions.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there presently opportunities to join this research endeavor?
"Unfortunately, at the present time this trial is not accepting new participants. The initial posting was on March 11th 2009 and it underwent its most recent edit on November 22nd 2022. If you're seeking other trials of interest, there are 1064 studies for colorectal cancer currently recruiting and 836 drug-focused investigations in search of volunteers."
To what extent are individuals safeguarded in pharmacological research?
"Our team at Power assigned the pharmacological study a score of 1 on our safety rating scale, as it is currently in its initial trial phase with limited research supporting both efficacy and safety."
Has any additional research been conducted on pharmaceuticals in relation to this subject?
"Currently, there are 836 studies being conducted on pharmacological study with 262 of them in Phase 3. Although Guangzhou and Guangdong house the majority of these experiments, trials for this research topic can be found at 37 410 locations across the world."
To what end is a pharmacological study typically conducted?
"Malignant neoplasms can often be managed with pharmacological study. This method of treatment may also prove useful for those struggling with recurrent platinum sensitive primary peritoneal cancer, rectal carcinoma, and locally advanced nonsquamous non-small cell lung cancer."
How many individuals are eligible to partake in this research endeavor?
"This clinical trial is not presently looking for people to participate. It was initially posted on March 11, 2009 and its last update occurred on November 22, 2022. For those searching for alternative research projects, 1064 studies are actively recruiting colorectal cancer patients while 836 trials seek volunteers for pharmacological experiments."
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