THC + Beta-Myrcene Effects on Cannabis Use
What You Need to Know Before You Apply
What is the purpose of this trial?
This study will evaluate the pharmacokinetics and pharmacodynamics of vaporized b-myrcene and THC administered via inhalation.
Do I need to stop taking my current medications to join the trial?
Yes, you may need to stop taking certain medications. You cannot use over-the-counter drugs, supplements, or vitamins within 14 days of the study sessions, and prescription medications must be stopped within a specific time frame unless they are birth control.
Is THC and Beta-Myrcene treatment generally safe for humans?
Research shows that cannabis-based treatments, including THC, are generally safe with a low incidence of severe side effects, though common mild side effects include nausea, dry mouth, dizziness, and sleepiness. Women may experience more adverse effects than men, possibly due to different cannabis compositions used.12345
How is the THC + Beta-Myrcene drug different from other cannabis-based drugs?
The THC + Beta-Myrcene drug is unique because it explores the potential synergy between THC and the terpenoid beta-myrcene, which may enhance therapeutic effects and reduce side effects compared to using THC alone. This combination leverages the 'entourage effect', where different cannabis compounds work together to potentially improve outcomes in treating conditions like pain and anxiety.678910
What evidence supports the effectiveness of the drug THC + Beta-Myrcene for reducing cannabis use?
Research shows that dronabinol (oral THC) has been studied for its effects on cannabis withdrawal and cognitive performance, suggesting potential benefits for cannabis use disorders. Additionally, cannabinoids, including THC, have shown therapeutic potential in various conditions, indicating their possible effectiveness in managing cannabis use.1112131415
Who Is on the Research Team?
Ryan Vandrey, PhD
Principal Investigator
Johns Hopkins University
Are You a Good Fit for This Trial?
This trial is for adults aged 18-55 in good health with a BMI of 18-36 kg/m2. Participants must not be pregnant, nursing, or have high blood pressure; they should test negative for drugs (except cannabis) and demonstrate cognitive competency. Those using certain medications or with significant medical/psychiatric conditions are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants complete 9 acute drug administration periods with THC, myrcene, or placebo in a randomized order
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Beta-Myrcene
- THC
Find a Clinic Near You
Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Collaborator